(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc.
(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc.
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DOI：
10.1016/j.heliyon.2017.e00497
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发表时间：
2018-01
期刊：
影响因子：
4
通讯作者：
Tanimori T
中科院分区：
文献类型：
--
作者：
Hayakawa T;Hatsukawa Y;Tanimori T
我们研究了95gTc和96gTc作为医用放射性同位素99mTc的替代品。96gTc （95gTc）可以通过（p, n）反应在浓缩的96Mo （95Mo）靶上产生，质子束由小型加速器提供，如医用回旋加速器，为正电子发射断层扫描（PET）产生放射性同位素。γ射线用电子跟踪康普顿照相机（ETCC）测量。我们计算了95gTc和96gTc的γ射线的相对强度。96gTc （95gTc）核的γ射线强度是99mTc核的63%（70%）。我们还计算了95gTc和96gTc的患者辐射剂量，根据应用假设，95gTc和96gTc的患者辐射剂量比99mTc大2-3倍。医用PET回旋加速器可提供能量为11-12 MeV、电流为100 μA的质子束，运行时间为8 h，可产生12 GBq (39 GBq) 96gTc (95gTc)，可进行240（200）次诊断扫描。
We studied 95gTc and 96gTc as alternatives to the medical radioisotope 99mTc. 96gTc (95gTc) can be produced by (p, n) reactions on an enriched 96Mo (95Mo) target with a proton beam provided by a compact accelerator such as a medical cyclotron that generate radioisotopes for positron emission tomography (PET). The γ-rays are measured with an electron-tracking Compton camera (ETCC). We calculated the relative intensities of the γ-rays from 95gTc and 96gTc. The calculated γ-ray intensity of a 96gTc (95gTc) nucleus is as high as 63% (70%) of that of a 99mTc nucleus. We also calculated the patient radiation doses of 95gTc and 96gTc, which were larger than that of 99mTc by a factor of 2–3 based on the applied assumptions. A medical PET cyclotron which can provide proton beams with energies of 11–12 MeV and a current of 100 μA can produce 12 GBq (39 GBq) of 96gTc (95gTc) for operation time of 8 h, which can be used for 240 (200) diagnostic scans.