Proteogenomic Review of the Changes in Primate apoC-I during Evolution.
Proteogenomic Review of the Changes in Primate apoC-I during Evolution.
复制标题
灵长类 apoC-I 进化过程中变化的蛋白质组学综述。
DOI：
10.1007/s11515-013-1278-7
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Whitelegge,JulianP
中科院分区：
文献类型：
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作者：
Puppione,Donald;Whitelegge,JulianP
载脂蛋白C-I的进化比任何其他可溶性载脂蛋白都要快。在灵长类进化过程中，这种载脂蛋白的基因被复制。我们观察到这两个基因编码两种不同形式的apoC-I在类人猿，我们已经审查了基因组和蛋白质组数据，以研究在灵长类动物进化过程中发生了什么变化。我们发现的数据表明，其中一个复制基因，已知是人类的假基因，也是丹尼索瓦人和尼安德特人的假基因。使用灵长类动物的基因组和蛋白质组学数据，我们将提供在本次审查的证据，复制后发生的分歧，新世界的猴子从人类谱系和假基因的形成后发生的分歧，倭黑猩猩和黑猩猩从人类谱系。
Apolipoprotein C-I has evolved more rapidly than any of the other soluble apolipoproteins. During the course of primate evolution, the gene for this apolipoprotein was duplicated. Prompted by our observation that the two resulting genes encode two distinct forms of apoC-I in great apes, we have reviewed both the genomic and proteomic data to examine what changes have occurred during the course of primate evolution. We have found data showing that one of the duplicated genes, known to be a pseudogene in humans, was also a pseudogene in Denisovans and Neandertals. Using genomic and proteomic data for primates, we will provide in this review evidence that the duplication took place after the divergence of New World monkeys from the human lineage and that the formation of the pseudogene took place after the divergence of the bonobos and chimpanzees from the human lineage.