Markedly Elevated Serum Level of T-Helper Cell 17-Related Cytokines/Chemokines in Acute Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.
Markedly Elevated Serum Level of T-Helper Cell 17-Related Cytokines/Chemokines in Acute Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.
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急性髓鞘少突胶质细胞糖蛋白抗体相关视神经炎中 T 辅助细胞 17 相关细胞因子/趋化因子的血清水平显着升高
DOI：
10.3389/fneur.2020.589288
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发表时间：
2020
影响因子：
3.4
通讯作者：
Wei S
中科院分区：
文献类型：
--
作者：
Kang H;Li H;Ai N;Liu H;Xu Q;Tao Y;Wei S
目的：本研究旨在探讨髓鞘少突胶质细胞糖蛋白抗体（MOG-IgG）阳性和阴性组在免疫发病机制上的差异。方法：将74份血清样本分为健康对照（HC）组（n = 15）、特发性脱髓鞘性视神经炎（IDON）组（n = 20）、水通道蛋白4 (AQP4)- igg阳性视神经炎（ON）组（n = 18）和MOG-IgG阳性ON组（n = 21），测定其t辅助细胞17 （Th17）细胞相关细胞因子/趋化因子水平。检测血清il - 17、il - 21、il - 28、il - 31、CXCL1、CXCL2、CCL2、CCL11、CCL20和LT-α。结果：与所有mog - igg阴性ON患者相比，mog - igg阳性ON患者血清中Th17细胞相关细胞因子/趋化因子明显升高。MOG-IgG阳性的ON患者血清il - 17和il - 21明显高于其他三组。MOG-IgG阳性的ON患者血清il - 28、il - 31、CXCL1、CCL11水平高于HC组和IDON组。mog - igg阳性和aqp4 - igg阳性组血清CCL2、CXCL2和CCL20浓度高于HC组。各组间血清LT-α水平无显著差异。调整后的多元回归分析显示，ON患者血清中il - 17和il - 21水平与MOG-IgG浓度呈正相关。结论：血清Th17细胞相关细胞因子/趋化因子水平升高可能在mog - igg阳性脱髓鞘性ON的发病机制中起重要作用。
Purpose: The purpose of this study was to examine the differences in immunopathogenesis based on the cytokine/chemokine profiles in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-positive and -negative groups. Methods: We measured the levels of T-helper cell 17 (Th17) cell-related cytokines/chemokines in 74 serum samples, which were divided into four groups: healthy control (HC) group (n = 15), idiopathic demyelinating optic neuritis (IDON) group (n = 20), aquaporin 4 (AQP4)-IgG-positive optic neuritis (ON) group (n = 18), and MOG-IgG positive-ON group (n = 21). Serum IL17, IL21, IL28, IL31, CXCL1, CXCL2, CCL2, CCL11, CCL20, and LT-α were detected. Results: The serum of the MOG-IgG-positive ON patients showed an obvious elevation of Th17 cell-related cytokines/chemokines compared with that of all the MOG-IgG-negative ON patients. Serum IL17 and IL21 were significantly higher in the ON patients with MOG-IgG positive than in all the other three groups. The serum levels of IL28, IL31, CXCL1, and CCL11 were higher in the ON patients with MOG-IgG positive than in the HC group and the IDON group. The serum concentration of CCL2, CXCL2, and CCL20 in the MOG-IgG-positive and AQP4-IgG-positive group is higher than that of the HC group. No difference in serum LT-α level was found among the four groups. Adjusted multiple regression analyses showed a positive association of IL17 and IL21 levels with the serum concentration of MOG-IgG in the ON patients. Conclusion: The elevated serum level of Th17 cell-related cytokine/chemokines may play an important role in the pathogenesis of MOG-IgG-positive demyelinating ON.
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影响因子：
6.4
作者：
Jarius, Sven;Wildemann, Brigitte
通讯作者：
Wildemann, Brigitte
影响因子：
4.4
作者：
Lindsey, J. W.;Meulmester, K. M.;Wolinsky, J. S.
通讯作者：
Wolinsky, J. S.
影响因子：
30.5
作者：
Reboldi, Andrea;Coisne, Caroline;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
12.8
作者：
Knier, Benjamin;Rothhammer, Veit;Korn, Thomas
通讯作者：
Korn, Thomas
影响因子：
4.8
作者：
Huppert, Jula;Closhen, Dorothea;Kuhlmann, Christoph R. W.
通讯作者：
Kuhlmann, Christoph R. W.