BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
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DOI：
10.1172/jci7830
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发表时间：
1999-11-01
影响因子：
15.9
通讯作者：
Uguccioni, M
中科院分区：
文献类型：
--
作者：
Mazzucchelli, L;Blaser, A;Uguccioni, M
幽门螺杆菌（Hp）感染可诱导胃内淋巴组织的形成，偶尔也会发生原发性胃B细胞淋巴瘤。我们研究了两种趋化因子的表达，吸引B淋巴细胞，BCA-1和SLC，在胃组织样本中获得的慢性胃炎患者诱导的Hp感染或非甾体类抗炎药，以及从患者Hp相关的低级别和高级别的胃淋巴瘤。BCA-1及其受体CXCR 5在Hp诱导的胃粘膜相关淋巴组织（MALT）中的所有粘膜淋巴聚集体和所有次级淋巴滤泡的套区中均观察到高水平表达。滤泡树突状细胞和B淋巴细胞是BCA-1的可能来源，而T淋巴细胞、巨噬细胞或CD 1a（+）树突状细胞不表达BCA-1。在胃MALT淋巴瘤的转化B细胞中也检测到BCA-1和CXCR 5的强表达。相比之下，SLC几乎仅限于淋巴组织内外的内皮细胞。在MALT卵泡的边缘区仅观察到少量、偶尔的SLC表达。我们的研究结果表明，BCA-1，作为一个归巢的趋化因子在正常的淋巴组织，诱导慢性Hp胃炎，并参与淋巴滤泡和胃淋巴瘤的MALT型的形成。
Infection with Helicobacter pylori (Hp) induces the formation of lymphoid tissue in the stomach and the occasional development of primary gastric B-cell lymphomas. We have studied the expression of 2 chemokines that attract B lymphocytes, BCA-1 and SLC, in gastric tissue samples obtained from patients with chronic gastritis induced by Hp infection or nonsteroidal anti-inflammatory drugs, as well as from patients with Hp-associated low-grade and high-grade gastric lymphomas. High-level expression of BCA-1 and its receptor, CXCR5, was observed in all mucosal lymphoid aggregates and in the mantle zone of all secondary lymphoid follicles in Hp-induced gastric mucosa-associated lymphoid tissue (MALT). Follicular dendritic cells and B lymphocytes are possible sources of BCA-1, which is not expressed by T lymphocytes, macrophages, or CD1a(+) dendritic cells. Strong expression of BCA-1 and CXCR5 was also detected in the transformed B cells of gastric MALT lymphomas. By contrast, SLC was confined almost exclusively to endothelial cells in and outside the lymphoid tissue. Only scant, occasional SLC expression was observed in the marginal zone of MALT follicles. Our findings indicate that BCA-1, which functions as a homing chemokine in normal lymphoid tissue, is induced in chronic Hp gastritis and is involved in the formation of lymphoid follicles and gastric lymphomas of the MALT type.