Simultaneous viral infections in immunocompetent infants with bronchiolitis: a prospective study.
Simultaneous viral infections in immunocompetent infants with bronchiolitis: a prospective study.
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DOI：
10.1016/s0929-693x(00)80180-3
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发表时间：
2000-06-01
影响因子：
1.8
通讯作者：
Duhamel, JF
中科院分区：
文献类型：
--
作者：
Brouard, J;Freymuth, F;Duhamel, JF
对202例免疫功能正常的毛细支气管炎婴儿进行了前瞻性的病毒感染性质研究。通过免疫荧光试验、病毒分离技术和聚合酶链反应杂交试验对鼻吸出物进行评价。在55名婴儿（27%）中检测到一种以上的呼吸道病毒。轮状病毒感染40例（20%），与呼吸道病毒感染无关，以呼吸道合胞病毒感染为主（46/55），并以呼吸道合胞病毒与腺病毒联合感染最多（21/55）。根据年龄、体重、新生儿疾病、既往个人或家族性特应性病史、中心温度、Silverman指数、氧依赖性住院时间、微生物学数据，单病毒感染与同时病毒感染之间无差异。没有迹象表明，同时病毒感染与免疫功能正常的婴儿毛细支气管炎的严重程度增加。(C)2000年，Elsevier SAS科学与医学版。
The nature of viral infection was prospectively investigated in 202 immunocompetent infants with bronchiolitis. Nasal aspirates were evaluated by immunofluorescence assay viral isolation technique and polymerase-chain-reaction-hybridization assay. In 55 infants (27 %) more than one respiratory virus were detected. A Rotavirus was found in 40 infants (20 %), without any relationship with the respiratory viral status, respiratory syncytial virus being the main virus (46/55), and the association of respiratory syncytial virus and adenovirus being the most frequent (21/55). No difference was found between monoviral infections on the one hand and simultaneous viral infections on the other hand according to age, weight, neonatal disease, past history of personal or familial atopy; central temperature, Silverman's index, oxygen dependency length of hospitalization, microbiology data. There was no indication that simultaneous virus infections were associated with an increased severity of the bronchiolitis in immunocompetent infants. (C) 2000 Editions scientifiques et medicales Elsevier SAS.