Do epileptic seizures damage the brain?
Do epileptic seizures damage the brain?
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DOI：
10.1097/00019052-200304000-00012
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发表时间：
2003-04-01
影响因子：
4.8
通讯作者：
Pitkänen, A
中科院分区：
文献类型：
--
作者：
Sutula, TP;Hagen, J;Pitkänen, A
综述的目的癫痫控制不佳患者的复发性癫痫发作可能会导致神经元损伤，并导致在某些癫痫患者中观察到的进行性功能和认知下降，这对治疗的紧迫性和有效干预以实现完全控制具有重要的临床和治疗意义。在细胞和分子水平上对神经元死亡进行实验分析的技术和概念进展，长期的神经心理学观察为癫痫发作现象提供了大量的新数据和见解，在神经回路中诱导可塑性，以解决“癫痫发作是否会损害大脑？”新出现的观点是，脑损伤不仅应被视为神经元的损失，而且应被视为长期的不良行为和认知后果。这一观点为开发神经保护性治疗以预防反复发作的不良长期后果以及实现完全控制发作的及时有效干预的重要性提供了强有力的理论基础。
Purpose of reviewThe possibility that recurrent seizures in patients with poorly controlled epilepsy may produce neuronal damage and contribute to progressive functional and cognitive declines observed in some patients with epilepsy has major clinical and therapeutic implications for urgency of treatment and effective intervention to achieve complete control.Recent findingsAdvances in magnetic resonance imaging techniques, technical and conceptual advances in experimental analysis of neuronal death at the cellular and molecular level, and long-term neuropsychological observations have provided substantial new data and insights into phenomena of seizure-induced plasticity in neural circuitry that address the question 'Do epileptic seizures damage the brain?'SummaryThe emerging perspective is that seizure-induced damage should be regarded not only as neuronal loss but as adverse long-term behavioral and cognitive consequences. This perspective provides a strong rationale for development of neuroprotective treatments to forestall adverse long-term consequences of repeated seizures, and for the importance of prompt, effective intervention that achieves complete seizure control.