New concepts in feedback regulation of glucose metabolism.
New concepts in feedback regulation of glucose metabolism.
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DOI：
10.1016/j.coisb.2017.11.005
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发表时间：
2018-04-01
影响因子：
3.7
通讯作者：
Locasale, Jason W
中科院分区：
文献类型：
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作者：
Locasale, Jason W
糖酵解，即葡萄糖的分解，是最保守且研究最广泛的生化途径之一。化学和热力学的设计原理允许能量生产、生物合成和细胞通信。然而，通过该途径的动力学或代谢通量也决定了其功能。最近，已经有许多进展建立了糖酵解酶与小分子代谢物的新变构相互作用以及其他可能合作以允许糖酵解的复杂调节的机制。本综述调查了这些新发现的糖酵解调节来源，并讨论了它们在建立糖酵解动力学设计原理中可能发挥的作用。
Glycolysis, the breakdown of glucose, is one of the most conserved and extensively studied biochemical pathways. Designing principles from chemistry and thermodynamics allow for energy production, biosynthesis and cellular communication. However, the kinetics or metabolic flux through the pathway also determines its function. Recently, there have been numerous developments that establish new allosteric interactions of glycolytic enzymes with small molecule metabolites and other mechanisms that may cooperate to allow for addition complex regulation of glycolysis. This review surveys these newfound sources of glycolysis regulation and discusses their possible roles in establishing kinetic design principles of glycolysis.