Altered brain activation and functional connectivity in working memory related networks in patients with type 2 diabetes: An ICA-based analysis.
Altered brain activation and functional connectivity in working memory related networks in patients with type 2 diabetes: An ICA-based analysis.
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DOI：
10.1038/srep23767
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发表时间：
2016-03-29
影响因子：
4.6
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Zhang Y;Lu S;Liu C;Zhang H;Zhou X;Ni C;Qin W;Zhang Q
2型糖尿病（T2 DM）可引起多方面的认知功能障碍，其中工作记忆（WM）通常在早期就已受累。然而，T2 DM患者WM受损的神经底物仍不清楚。为了澄清这个问题，我们利用功能磁共振成像（fMRI）和独立成分分析来评估T2 DM患者的大脑激活和功能连接（FC）在WM网络的改变，并确定其与认知和临床变量的关联。20名无并发症的T2 DM患者和19名匹配的健康对照（HC）被招募，并在块设计的1-back WM任务期间获得fMRI数据。T2 DM患者的WM指标与HC相比无差异，但T2 DM患者的准确率略低。与HC相比，T2 DM患者的WM额顶网络激活增强，激活强度与WM表现显著相关。2型糖尿病患者也表现出减少FC内和之间的WM网络。我们的研究结果表明，WM子网络的功能整合在无并发症的T2 DM患者中被破坏，额顶叶网络的区域活动增强可能会补偿T2 DM引起的WM损伤。
Type 2 diabetes mellitus (T2DM) can cause multidimensional cognitive deficits, among which working memory (WM) is usually involved at an early stage. However, the neural substrates underlying impaired WM in T2DM patients are still unclear. To clarify this issue, we utilized functional magnetic resonance imaging (fMRI) and independent component analysis to evaluate T2DM patients for alterations in brain activation and functional connectivity (FC) in WM networks and to determine their associations with cognitive and clinical variables. Twenty complication-free T2DM patients and 19 matched healthy controls (HCs) were enrolled, and fMRI data were acquired during a block-designed 1-back WM task. The WM metrics of the T2DM patients showed no differences compared with those of the HCs, except for a slightly lower accuracy rate in the T2DM patients. Compared with the HCs, the T2DM patients demonstrated increased activation within their WM fronto-parietal networks, and activation strength was significantly correlated with WM performance. The T2DM patients also showed decreased FC within and between their WM networks. Our results indicate that the functional integration of WM sub-networks was disrupted in the complication-free T2DM patients and that strengthened regional activity in fronto-parietal networks may compensate for the WM impairment caused by T2DM.