Immunological responses to oxidized LDL
Immunological responses to oxidized LDL
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DOI：
10.1016/s0891-5849(00)00333-6
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发表时间：
2000-06-15
影响因子：
7.4
通讯作者：
Witztum, JL
中科院分区：
文献类型：
--
作者：
Hörkkö, S;Binder, CJ;Witztum, JL
现在有大量证据表明免疫系统在动脉粥样硬化实验模型中起着重要作用。我们回顾了越来越多的证据，即低密度脂蛋白（LDL）的氧化产生了多种新自身决定簇，从而导致细胞免疫和体液免疫反应。特别是，我们已经证明，在氧化的LDL颗粒上产生的至少一些氧化特异性表位，例如氧化磷脂表位，也在凋亡细胞上产生，并且也存在于一些细菌的表面。许多这些相同的表位作为重要的配体，介导氧化损伤的脂蛋白颗粒和凋亡细胞的结合与清除，对这些表位的先天免疫反应可被视为一种协同反应以实现它们的清除。此外，氧化型LDL的其他表位无疑也在以进行性动脉粥样硬化斑块为特征的免疫激活中起作用。确定这些反应作用的重要性以及了解哪些是有益的，哪些是有害的，将是非常重要的。这些信息有朝一日可能会导致利用操纵免疫反应的能力来抑制动脉粥样硬化形成的新的治疗方法。（C）2000爱思唯尔科学公司
Considerable evidence now points to an important role for the immune system in experimental models of atherosclerosis. We have reviewed the growing body of evidence that oxidation of LDL generates a wide Variety of neoself determinants that lead to cellular and humoral immune responses. In particular, we have demonstrated that at least some of the oxidation-specific epitopes generated on the oxidized LDL particle, such as oxidized phospholipid epitopes, are also generated on apoptotic cells and are also present on the surface of some bacteria. Many of these same epitopes serve as important ligands mediating the binding and clearance of oxidatively damaged lipoprotein particles and apoptotic cells, and the innate immune response to these epitopes can be seen as a conserted response to effect their removal. In addition, other epitopes of OxLDL also undoubtedly play a role in the immune activation that characterizes the progressive atherosclerotic plaque. It will be of great importance to define the importance of the role of these responses and to understand which are beneficial and which deleterious. Such information could lead one day to novel therapeutic approaches to inhibit atherogenesis that take advantage of the ability to manipulate the immune response. (C) 2000 Elsevier Science Inc.