Balancing selection and MHC
Balancing selection and MHC
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DOI：
10.1023/a:1026494212540
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发表时间：
1998-01-01
期刊：
影响因子：
1.5
通讯作者：
Hedrick, PW
中科院分区：
文献类型：
--
作者：
Hedrick, PW
在大多数脊椎动物中，MHC是高度多态性的，维持这种变异的选择性机制有几种，包括母胎相互作用、寄生虫抗性和负分类交配。对这些机制的证据进行了审查，并给出了若干研究中选择量的估计。尽管关于MHC平衡选择的机制和程度还有很多有待了解的地方，但分子遗传技术的新进展和许多类型的生物学家对MHC的兴趣日益增加，有望在不久的将来找到答案。
The MHC is highly polymorphic in most vertebrates and the suggested selective mechanisms responsible for the maintenance of this variation are several, including maternal-fetal interaction, parasite resistance, and negative-assortative mating. Evidence for these mechanisms is reviewed and estimates of the amount of selection in a number of studies are given. Although there is much yet to be understood about the mechanism and extent of balancing selection at MHC, new advances in molecular genetic technology and increasing interest in MHC from many types of biologists promise answers in the near future.