13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis.
13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis.
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DOI:
10.1093/bioinformatics/bts646
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发表时间:
2013-01-01
期刊:
影响因子:
--
通讯作者:
Wiechert W
中科院分区:
文献类型:
--
作者:
Weitzel M;Nöh K;Dalman T;Niedenführ S;Stute B;Wiechert W
Summary: 13C-based metabolic flux analysis (13C-MFA) is the state-of-the-art method to quantitatively determine in vivo metabolic reaction rates in microorganisms. 13CFLUX2 contains all tools for composing flexible computational 13C-MFA workflows to design and evaluate carbon labeling experiments. A specially developed XML language, FluxML, highly efficient data structures and simulation algorithms achieve a maximum of performance and effectiveness. Support of multicore CPUs, as well as compute clusters, enables scalable investigations. 13CFLUX2 outperforms existing tools in terms of universality, flexibility and built-in features. Therewith, 13CFLUX2 paves the way for next-generation high-resolution 13C-MFA applications on the large scale. Availability and implementation: 13CFLUX2 is implemented in C++ (ISO/IEC 14882 standard) with Java and Python add-ons to run under Linux/Unix. A demo version and binaries are available at www.13cflux.net. Contact: info@13cflux.net or k.noeh@fz-juelich.de Supplementary information: Supplementary data are available at Bioinformatics online.
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