Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models
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DOI：
10.1007/s11418-009-0367-z
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Suleyman, Halis
中科院分区：
文献类型：
--
作者：
Tanas, Sevil;Odabasoglu, Fehmi;Suleyman, Halis
研究了地衣植物紫花菜Peltigera rufescens(Weis.)以角叉菜胶诱导的急性炎症(角叉菜胶致炎症)和慢性炎症(棉球颗粒)为实验对象，研究了胡麻素(MEPR)的抗炎作用。MEPR能减轻角叉菜胶诱导的炎症反应，并在慢性炎症模型中显示出强大的抗增殖作用(63.5%)。炎症与中性粒细胞的渗透以及中性粒细胞衍生的介质和自由基的产生有关。MEPR可降低髓过氧化物酶和诱导型一氧化氮合酶(NOS)活性，而角叉菜胶能使其活性升高。角叉菜胶组与未处理组相比，其脂质过氧化反应(LPO)也明显增加。MEPR、双氯芬酸和消炎痛的应用通过改善抗氧化防御系统降低了爪子组织中的LPO。因此，中性粒细胞在组织中的渗透和中性粒细胞衍生的自由基在角叉菜胶诱导的炎症过程中起着重要作用。MEPR的抗炎作用可能与其降低中性粒细胞产生的自由基和改善抗氧化防御系统有关。
The anti-inflammatory effects of the methanol extract of the lichen species Peltigera rufescens (Weis.) Humb (MEPR) (Peltigeraceae) on acute (carrageenan-induced) and chronic (cotton pellet granule) phases of inflammation were investigated. The MEPR was capable of reducing carrageenan-induced inflammation and showed a potent antiproliferative effect (63.5%) in the chronic inflammation model. Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals. The MEPR reduced the myeloperoxidase and inducible nitric oxide synthase (NOS) activities, which were increased by carrageenan injection. Carrageenan injection also increased the lipid peroxidation (LPO) as compared with untreated paw tissues. The administration of MEPR, diclofenac, and indomethacin reduced the LPO in paw tissues through amelioration of the antioxidant defense systems. Neutrophil infiltration and neutrophil-derived free radicals in tissues therefore appeared to play an important role in the inflammation process induced by carrageenan. The anti-inflammatory effect of MEPR could be attributed to its reducing effect on the neutrophil-derived free radicals and its ameliorating effect on the antioxidant defense systems.