N,N′-Ditosylhydrazine:: A convenient reagent for facile synthesis of Diazoacetates
N,N′-Ditosylhydrazine:: A convenient reagent for facile synthesis of Diazoacetates
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DOI：
10.1021/ol701432k
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发表时间：
2007-08-02
期刊：
影响因子：
5.2
通讯作者：
Fukuyama, Tohru
中科院分区：
文献类型：
--
作者：
Toma, Tatsuya;Shimokawa, Jun;Fukuyama, Tohru
公开了合成重氮乙酸酯的新方法。以相应的溴代乙酸酯为原料，经N，N ′-二甲苯酰肼处理，合成了一系列重氮乙酸酯，产率较高。稳定的结晶试剂易于操作，反应时间短，是传统方法的一种有用的替代方法。
[GRAPHICS]A novel entry to the synthesis of diazoacetates is disclosed. A variety of diazoacetates were synthesized from the corresponding bromoacetates by treatment with N,N'-ditosylhydrazine in moderate to high yields. Ease of operation with the stable crystalline reagent as well as a short reaction time offer a useful alternative to the conventional methods.