Effects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation Putative mechanism for aggravating vascular disease in diabetes
Effects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation Putative mechanism for aggravating vascular disease in diabetes
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DOI：
10.2337/dc10-0013
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发表时间：
2010-07-01
期刊：
影响因子：
16.2
通讯作者：
Frier, Brian M.
中科院分区：
文献类型：
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作者：
Wright, Rohana J.;Newby, David E.;Frier, Brian M.
目的：探讨急性胰岛素诱导低血糖对成人1型糖尿病患者炎症反应、内皮功能障碍和血小板活化的影响。研究设计与方法：研究对象为16例非糖尿病成人和16例1型糖尿病患者，分别在正常血糖(血糖4.5 mm o l/L)和低血糖(血糖2.5 m o l/L)状态下进行研究。检测炎症、血栓形成和内皮功能障碍的指标(可溶性P-选择素、白介素6、血管性血友病因子[vWF]、组织纤溶酶原激活物[tPA]、高敏C反应蛋白[hsCRP]和可溶性CD40配体[sCD40L])；采用流式细胞术检测血小板-单核细胞聚集和单核细胞表面CD40表达。
OBJECTIVE - To examine the effects of acute insulin-induced hypoglycemia on inflammation, endothelial dysfunction, and platelet activation in adults with and without type 1 diabetes.RESEARCH DESIGN AND METHODS - We studied 16 nondiabetic adults and 16 subjects with type 1 diabetes during euglycemia (blood glucose 4.5 mmol/l) and hypoglycemia (blood glucose 2.5 mmol/l). Markers of inflammation, thrombosis, and endothelial dysfunction (soluble P-selectin, interleukin-6, von Willebrand factor [vWF], tissue plasminogen activator [tPA], high-sensitivity C-reactive protein [hsCRP], and soluble CD40 ligand [sCD40L]) were measured; platelet-monocyte aggregation and CD40 expression on monocytes were determined using flow cytometry.RESULTS - In nondiabetic participants, platelet activation occurred after hypoglycemia, with increments in platelet-monocyte aggregation and P-selectin (P