Aged atria: electrical remodeling conducive to atrial fibrillation.
Aged atria: electrical remodeling conducive to atrial fibrillation.
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DOI：
10.1007/s10840-008-9358-3
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发表时间：
2009-06
影响因子：
1.8
通讯作者：
Boyden, Penelope A.
中科院分区：
文献类型：
--
作者：
Dun, Wen;Boyden, Penelope A.
心房颤动（AF）的发病率随着年龄的增长而增加。与衰老相关的心房离子通道结构和功能的改变为房颤提供了基础。在这篇综述中，我们概述了目前关于心房年龄相关变化的知识，重点是内在离子通道功能、脉冲启动和传导。对心房动作电位（AP）的研究表明，AP轮廓随着年龄的增长而改变，AP参数的离散度随着年龄的增长而增加。然而，使用人体组织进行的研究与实验动物研究并不完全一致，因为来自人类的标本是从伴有心血管疾病和/或受到药物影响的心脏中获得的。离子电流研究表明，虽然心房组织中钠电流没有与年龄相关的变化，但老年细胞中钙电流减少，瞬时外向和持续钾电流增加。虽然窦房结放电随着年龄的增长而减少，但老年心房细胞（如肺静脉和冠状窦）的脉冲起始可能会增强。老年心房纤维组织增多，这与异常电传导的可能性增加有关。因此，与年龄相关的房颤涉及基质的改变以及老年心房被动特性的改变。
The incidence of atrial fibrillation (AF) increases with age. Alterations in structure and function of atrial ion channels associated with aging provide the substrate for AF. In this review we provide an overview of current knowledge regarding these age-related changes in atria, focusing on intrinsic ion channel function, impulse initiation and conduction. Studies on the action potentials (APs) of atria have shown that the AP contour is altered with age and the dispersion of AP parameters is increased with age. However, studies using human tissues are not completely consistent with experimental animal studies, since specimens from humans have been obtained from hearts with concomitant cardiovascular diseases and/or that are under the influence of pharmacologic agents. Ionic current studies show that while there are no age-related changes in sodium currents in atrial tissue, the calcium current is reduced and the transient outward and sustained potassium currents are increased in aged cells. While sinoatrial node firing is reduced with age, enhanced impulse initiation may occur in aged atrial cells, for example in the pulmonary veins and coronary sinus. Fibrous tissue is increased in aged atria, which is associated with an increased likelihood of abnormal electrical conduction. Thus, age-related AF involves alterations in the substrate as well as in the passive properties of aged atria.
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