Nucleophilic Isocyanation
Nucleophilic Isocyanation
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DOI：
10.1021/acsomega.9b04073
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发表时间：
2020-03
期刊：
影响因子：
4.1
通讯作者：
Taiga Yurino;T. Ohkuma
中科院分区：
文献类型：
--
作者：
Taiga Yurino;T. Ohkuma
异腈经常被用作有机转化的底物和有机金属化学的配体。然而，尽管异腈化合物应用广泛，但其合成通常依赖于传统的n -甲酰胺脱水法。使用氰化物作为n -亲核试剂的“亲核异氰化”是另一种提供相应异腈的直接策略。这种方法自19世纪以来一直可用，但仍然是一种不成熟的程序，因此很少使用。本文综述了亲核异氰化的概念和最新进展，包括相对罕见的催化异氰化。
Isonitriles are frequently employed as both substrates for organic transformations and ligands for organometallic chemistry. However, despite the wide application of the isonitriles, their synthesis generally depends on the traditional dehydration of N-formamide. “Nucleophilic isocyanation” using cyanide as an N-nucleophile is another straightforward strategy affording the corresponding isonitriles. This method has been available since the 19th century but is still an immature procedure and is therefore more rarely used. In this review, we summarize the concepts and recent progress in nucleophilic isocyanation, including the relatively rare examples of catalytic isocyanation.