Characterizing gelatin hydrogel viscoelasticity with diffusing colloidal probe microscopy.
Characterizing gelatin hydrogel viscoelasticity with diffusing colloidal probe microscopy.
复制标题
用扩散胶体探针显微镜表征明胶水凝胶粘弹性。
DOI：
10.1016/j.jcis.2017.02.057
复制
发表时间：
2017
影响因子：
9.9
通讯作者：
Jaime J. Juárez
中科院分区：
文献类型：
--
作者：
Soheila Shabaniverki;Jaime J. Juárez
在这项研究中，我们使用扩散胶体探针显微镜（DCPM）来研究明胶水凝胶的粘弹性，直接测量胶体探针与底层粘弹性介质之间的弹性势能相互作用。明胶样品在0.3 wt%和0.6 wt%之间以四种不同的浓度制备，以检查粘弹性随浓度的变化。将胶体探针和水凝胶之间的相互作用描述为弹簧-阻尼器系统的力平衡可以得到均方位移的简单模型。胶体探针取样的位置直方图与明胶水凝胶的弹性势能和有效弹簧常数直接相关。有效弹簧常数是均方位移模型中用于求解有效粘度的一个固定参数。这些参数与通过二维均方位移的微流变分析获得的粘弹性参数相当。这些结果可以作为评估水凝胶系统的指南，其中粘弹性特性是生物材料设计中的重要因素。
In this study, we investigate viscoelasticity in gelatin hydrogels using diffusing colloidal probe microscopy (DCPM) to directly measure the elastic potential energy interaction between colloidal probes and the underlying viscoelastic media. Gelatin samples are prepared in four different concentrations between 0.3 wt% and 0.6 wt% to examine changes in viscoelasticity with concentration. A force balance describing the interaction between the colloidal probes and the hydrogel as a spring-damper system lead to a simple model for mean square displacement. A histogram of locations sampled by the colloidal probes is directly related to the elastic potential energy and the effective spring constant of the gelatin hydrogels. The effective spring constant is a fixed parameter used in the mean square displacement model to find effective viscosity. These parameters are comparable to viscoelastic parameters obtain by a microrheology analysis of two-dimensional mean square displacements. These results can serve as a guide for assessing hydrogel systems where viscoelastic properties are an important factor in biomaterial design.
影响因子：
3.4
作者：
Thompson, RE;Larson, DR;Webb, WW
通讯作者：
Webb, WW
影响因子：
14
作者：
Jia W;Gungor-Ozkerim PS;Zhang YS;Yue K;Zhu K;Liu W;Pi Q;Byambaa B;Dokmeci MR;Shin SR;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
3.4
作者：
Cheezum, MK;Walker, WF;Guilford, WH
通讯作者：
Guilford, WH