The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium.
The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium.
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DOI：
10.1155/2008/253817
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
Finck BN
中科院分区：
文献类型：
--
作者：
Duncan JG;Finck BN
哺乳动物心肌是一种杂食性器官，依靠多种基质来满足其巨大的能量需求。心脏能量代谢偏好在几个关键点上受到调节，包括基因转录水平。新的证据表明，核受体PPAR及其心脏富集的辅激活蛋白PGC-1在心肌能量代谢的转录控制中发挥重要作用。PPAR-PGC-1复合体控制着参与心脏脂肪酸和葡萄糖代谢以及线粒体生物发生的编码酶的基因表达。此外，有证据表明PPAR-PGC-1复合物的活性在几种病理生理条件下受到干扰，并且该途径活性的改变可能在心肌病重塑中发挥作用。在这篇综述中，我们详细介绍了PPAR-PGC-1轴在生理和病理生理刺激下调节线粒体能量代谢和心功能的作用。
The mammalian myocardium is an omnivorous organ that relies on multiple substrates in order to fulfill its tremendous energy demands. Cardiac energy metabolism preference is regulated at several critical points, including at the level of gene transcription. Emerging evidence indicates that the nuclear receptor PPAR and its cardiac-enriched coactivator protein, PGC-1, play important roles in the transcriptional control of myocardial energy metabolism. The PPAR-PGC-1 complex controls the expression of genes encoding enzymes involved in cardiac fatty acid and glucose metabolism as well as mitochondrial biogenesis. Also, evidence has emerged that the activity of the PPAR-PGC-1 complex is perturbed in several pathophysiologic conditions and that altered activity of this pathway may play a role in cardiomyopathic remodeling. In this review, we detail the current understanding of the effects of the PPAR-PGC-1 axis in regulating mitochondrial energy metabolism and cardiac function in response to physiologic and pathophysiologic stimuli.
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DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
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DOI：
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影响因子：
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