Antiviral activity of a sulfoquinovosyldiacylglycerol (SODG) compound isolated from the green alga Caulerpla racemosa
Antiviral activity of a sulfoquinovosyldiacylglycerol (SODG) compound isolated from the green alga Caulerpla racemosa
复制标题
从绿藻 Caulerpla racemosa 中分离出的磺基喹诺酮基二酰基甘油 (SODG) 化合物的抗病毒活性
DOI：
10.1515/bot.2007.022
复制
发表时间：
2007-01-01
期刊：
影响因子：
2.2
通讯作者：
Cen, Ying-zhou
中科院分区：
文献类型：
--
作者：
Wang, Hui;Li, Yao-lan;Cen, Ying-zhou
对采自中国南海的一种入侵性绿色藻总状蕨藻（Caulerpa racemosa）进行了抗病毒活性测定。所得热水提取物和正丁醇级分显示出对单纯疱疹病毒1型（HSV-1）和科萨基病毒B3（考克斯133）的有效抑制。一个磺基quinovosyldiacylglycerol（SQDG）化合物分离和纯化的正丁醇馏分进一步抗病毒导向分馏。SQDG化合物对HSV-2表现出优异的抗病毒效果，对HSV-2的标准和临床菌株的50%抑制浓度（IC 50）为15.6 μ g/ml，但对HSV-1和考克斯B3仅表现出中等的抗病毒效果。使用光谱方法将SQDG化合物化学表征为（2S）-1，2-二-O-棕榈酰基-3-O-（16 '-磺基-α-D-喹诺吡喃糖基）甘油。这是首次从C.该SQDG化合物的总状花序具有显著的针对HSV-2的选择性抗病毒活性。
An invasive green alga, Caulerpa racemosa, collected from the South China Sea was tested for its antiviral properties. Hot water extracts and the n-butanol fraction obtained showed potent inhibition of herpes simplex virus type 1 (HSV-1) and Coxsackie virus B3 (Cox 133). A sulfoquinovosyldiacylglycerol (SQDG) compound was isolated and purified from the n-butanol fraction following further antiviral-guided fractionation. The SQDG compound exhibited an excellent antiviral effect against HSV2, with a 50% inhibitory concentration (IC50) of 15.6 mu g ml(-1) against both standard and clinical strains of HSV-2, but showed only moderate antiviral effects against HSV1 and Cox B3. The SQDG compound was chemically characterized using spectroscopic methods as (2S)-1,2-di-O-palmitoyl-3-O-(16'-sulfo-alpha-D-quinovopyranosyl) glycerol. This is the first isolation from C. racemosa of this SQDG compound with notable selective antiviral activity against HSV-2.