Naming manipulable objects: Anatomy of a category specific effect in left temporal tumours
Naming manipulable objects: Anatomy of a category specific effect in left temporal tumours
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DOI：
10.1016/j.neuropsychologia.2010.02.002
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发表时间：
2010-05-01
期刊：
影响因子：
2.6
通讯作者：
Shallice, Tim
中科院分区：
文献类型：
--
作者：
Campanella, Fabio;D'Agostini, Serena;Shallice, Tim
语义知识是分类组织的，还是基于颞叶内的无差别分布式网络，或者至少部分地组织在基于属性的网络中，仍然是一个悬而未决的问题。与命名任务，涉及生活和非生活实体，后者划分根据程度的可操作性，我们研究了一组30例肿瘤患者，无论是右，左前或左后颞叶的病变和单纯疱疹病毒性脑炎患者（MU）。进行了跨学科和跨刺激分析。在命名任务中，左半球患者总体上比右半球患者和对照组差。此外，他们还将非生命的物品命名为比生命更糟糕的物品。这种影响是更大的左后颞比右颞和左前颞患者和显着的跨学科和跨刺激水平的分析。此外，左后颞部组比左前颞部患者更难处理高度可操作的物体，但仅在跨学科分析中效果显著。VLSM病变分析显示，与可操作物体的较大命名缺陷最关键相关的区域是左颞叶的后上级部分，特别是后颞中回。这些结果支持一个“基于属性的网络”帐户的语义知识，而不是一个“无差别的网络”帐户。对于可操纵的对象，这将是一个后颞/前顶叶左半球的“行动/操纵属性为基础的”网络相关的背侧通路，这被认为是重要的动作控制，神经影像学结果表明。(C)2010爱思唯尔有限公司保留所有权利。
Whether semantic knowledge is categorically organized or is based in an undifferentiated distributed network within the temporal lobes or it is at least partially organized in property-based networks is still an open issue. With a naming task involving living and nonliving entities, the latter divided according to degree of manipulability, we studied a group of 30 tumour patients with either right, left anterior or left posterior temporal lobes' lesions and a herpes simplex encephalitis patient (MU). Both cross-subject and cross-stimulus analyses were conducted. Left hemisphere patients were overall worse than both right hemisphere patients and controls in the naming task. They moreover named nonliving items worse than living. This effect was larger in left posterior temporal than both right temporal and also left anterior temporal patients and significant both at a cross-subject and cross-stimulus levels of analysis. In addition the left posterior temporal group had more difficulties with highly manipulable objects than left anterior temporal patients, but the effect was significant only on a cross-subject analysis. VLSM lesion analysis revealed that the area most critically associated with the larger naming deficit for manipulable objects was the posterior superior portion of the left temporal lobe, particularly the posterior middle temporal gyrus. These results support a 'property-based networks' account of semantic knowledge rather than an 'undifferentiated network' account. For manipulable objects, this would be a posterior-temporal/inferior-parietal left hemisphere "action/manipulation-property-based" network related to the dorsal pathways which is thought to be important in action control, as suggested by neuroimaging results. (C) 2010 Elsevier Ltd. All rights reserved.