Persistent pain and uncomfortable sensations in persons with multiple sclerosis
Persistent pain and uncomfortable sensations in persons with multiple sclerosis
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DOI：
10.1016/j.pain.2006.07.015
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发表时间：
2007-01-01
期刊：
影响因子：
7.4
通讯作者：
Vollmer, Timothy
中科院分区：
文献类型：
--
作者：
Hadjimichael, Olympia;Kerns, Robert D.;Vollmer, Timothy
疼痛的经验已在多发性硬化症（NIS）个体的小型研究中记录。本研究调查了在大型北美NIS研究委员会（NARCONIS）患者登记处的参与者中持续性疼痛和不舒服感觉的患病率。登记者（10，176）回答了关于疼痛的问卷，7579人报告在调查前一个月经历了一定程度的疼痛。在受访者中，49%的人报告轻度至重度疼痛，49%的人表示重度疼痛。疼痛强度增加与性别（更多女性）、多个疼痛部位（重度疼痛组报告4个或更多疼痛部位）和疼痛持续性（重度疼痛组中44%）呈正相关。与MS相关残疾、复发恶化型NIS和抑郁症的增加也呈正相关。患有严重疼痛的受访者更多地使用医疗保健系统和处方止痛药，但对医生管理疼痛的努力不太可能满意。大约三分之一的中度疼痛患者和18%的重度疼痛患者报告说，他们的疼痛没有得到咨询。疼痛严重程度的影响在受访者的日常生活、工作、情绪、娱乐活动和生活享受方面都很明显。我们的研究结果表明，MS相关的严重疼痛的高患病率，对剧烈疼痛的管理满意度低，以及对生活质量指标的感知干扰，需要医疗服务提供者更加关注NIS人群的疼痛和不适感的管理。(c)2006年国际疼痛研究协会。Elsevier B.V.出版，保留所有权利。
The experience of pain has been documented in small studies of individuals with multiple sclerosis (NIS). The present study examines the prevalence of persistent pain and uncomfortable sensations among participants in the large North American Research Committee on NIS (NARCONIS) Patient Registry. Registrants (10,176) responded to a questionnaire on pain and 7579 reported experiencing some level of pain during the month prior to the survey. Among the respondents 49% reported mild to severe pain and 49% of those indicated severe pain. Increased pain intensity was positively associated with gender (more women), multiple pain sites (5 1 OX) of the severe pain group reported four or more pain sites), and constancy of pain (44% among the group with severe pain). There was also a positive association with increased MS-related disability, relapsing-worsening type of NIS, and depression. Respondents with severe pain made greater use of the healthcare system and of prescribed analgesics, but were less likely to be satisfied with their doctors' efforts to manage their pain. About one-third of the patients with moderate pain and 18% of those with severe pain reported no consultations for their pain. The effects of pain severity were fully evident in the respondents' daily life, their work, mood, recreational activities and enjoyment of life. Our results indicate that the high prevalence of MS-related severe pain, low satisfaction with management of intense pain, and the perceived interference with quality of life indicators necessitate greater attention by healthcare providers to the management of pain and uncomfortable sensations in the NIS population. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.