Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease.
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease.
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DOI：
10.1002/jlb.3ru0121-023r
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发表时间：
2022-01
影响因子：
5.5
通讯作者：
Herbert DR
中科院分区：
文献类型：
--
作者：
Jean EE;Good O;Rico JMI;Rossi HL;Herbert DR
神经系统和免疫系统之间的通讯在包括呼吸道在内的粘膜屏障部位的宿主保护性免疫中起着关键作用。在这些组织中，神经免疫相互作用在双向回路中运作，可以感知和响应机械，化学和生物刺激。过敏原或蠕虫诱导的产物可通过直接作用于伤害性传入神经和邻近组织而产生气道炎症。伤害性传入神经的活动可以通过神经肽和神经递质信号传导调节先天性和适应性免疫反应。本文将总结最近的工作调查的作用，神经肽CGRP，VIP，神经调节素，P物质，神经递质多巴胺和B2肾上腺素受体激动剂肾上腺素/去甲肾上腺素，其中每一个影响2型免疫通过指示肥大细胞，先天性淋巴细胞2型，树突状细胞，T细胞反应，无论是在气道和引流淋巴结。气道中的传入物还含有警报素和细胞因子的受体，允许它们的活性被免疫细胞分泌的产物，特别是肥大细胞分泌的产物调节。总之，我们建议进一步研究免疫调节神经肽如何在实验系统中塑造呼吸道炎症，可能会发现新的治疗靶点，以解决人类慢性气道疾病日益增加的患病率。综述神经传入如何通过神经肽启动免疫反应，并通过CGRP，NMB，VIP和ARDB 2信号传导解决炎症和气道收缩。
Communication between the nervous and immune systems serves a key role in host‐protective immunity at mucosal barrier sites including the respiratory tract. In these tissues, neuroimmune interactions operate in bidirectional circuits that can sense and respond to mechanical, chemical, and biologic stimuli. Allergen‐ or helminth‐induced products can produce airway inflammation by direct action on nociceptive afferents and adjacent tissues. The activity of nociceptive afferents can regulate innate and adaptive immune responses via neuropeptides and neurotransmitter signaling. This review will summarize recent work investigating the role of neuropeptides CGRP, VIP, neuromedins, substance P, and neurotransmitters dopamine and the B2‐adrenoceptor agonists epinepherine/norepinepherine, each of which influence type 2 immunity by instructing mast cell, innate lymphoid cell type 2, dendritic cell, and T cell responses, both in the airway and the draining lymph node. Afferents in the airway also contain receptors for alarmins and cytokines, allowing their activity to be modulated by immune cell secreted products, particularly those secreted by mast cells. Taken together, we propose that further investigation of how immunoregulatory neuropeptides shape respiratory inflammation in experimental systems may reveal novel therapeutic targets for addressing the increasing prevalence of chronic airway disease in humans. Review of how neural afferents initiate immune responses via neuropeptides, and resolve inflammation and airway constriction via CGRP, NMB, VIP, and ARDB2 signaling.