Functional organization of perisylvian activation during presentation of sentences in preverbal infants
Functional organization of perisylvian activation during presentation of sentences in preverbal infants
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DOI：
10.1073/pnas.0606302103
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发表时间：
2006-09-19
影响因子：
11.1
通讯作者：
Dehaene, Stanislas
中科院分区：
文献类型：
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作者：
Dehaene-Lambertz, Ghislaine;Hertz-Pannier, Lucie;Dehaene, Stanislas
我们研究了3个月大的婴儿在听母语时大脑活动的功能组织。短句中提出了一个缓慢的事件相关的功能磁共振成像范例。然后，我们分析了婴儿的大脑外侧裂周围反应区域网络功能不同的地区的基础上，他们的激活速度和敏感性的句子重复。成年人一样的结构功能磁共振成像反应延迟观察沿着的上级颞区，这表明一个分层的处理方案。最快的反应被记录在附近的Heschl的回，而反应变得越来越慢的后部的上级颞回和颞极和额下区（布罗卡区）。在后一个区域的激活增加时，句子被重复14秒的延迟，这表明早期参与的布洛卡区的文字记忆。婴儿在牙牙学语之前，布罗卡区就很活跃，这一事实意味着，这个区域的活动并不是复杂运动学习的结果，相反，这个区域可能通过与知觉系统的相互作用，驱动对未来言语产生所需的复杂运动序列的学习。我们的研究结果指出，人类大脑在生命的最初几个月里有一个复杂的层次结构，这可能在我们物种的语言习得中起着至关重要的作用。
We examined the functional organization of cerebral activity in 3-month-old infants when they were listening to their mother language. Short sentences were presented in a slow event-related functional MRI paradigm. We then parsed the infant's network of perisylvian responsive regions into functionally distinct regions based on their speed of activation and sensitivity to sentence repetition. An adult-like structure of functional MRI response delays was observed along the superior temporal regions, suggesting a hierarchical processing scheme. The fastest responses were recorded in the vicinity of Heschl's gyrus, whereas responses became increasingly slower toward the posterior part of the superior temporal gyrus and toward the temporal poles and inferior frontal regions (Broca's area). Activation in the latter region increased when the sentence was repeated after a 14-s delay, suggesting the early involvement of Broca's area in verbal memory. The fact that Broca's area is active in infants before the babbling stage implies that activity in this region is not the consequence of sophisticated motor learning but, on the contrary, that this region may drive, through interactions with the perceptual system, the learning of the complex motor sequences required for future speech production. Our results point to a complex, hierarchical organization of the human brain in the first months of life, which may play a crucial role in language acquisition in our species.