Pretreatment angiogenic cytokines predict response to chemoimmunotherapy in patients with chronic lymphocytic leukaemia.
Pretreatment angiogenic cytokines predict response to chemoimmunotherapy in patients with chronic lymphocytic leukaemia.
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预处理血管生成细胞因子预测慢性淋巴细胞性白血病患者的化学免疫疗法的反应。
DOI：
10.1111/j.1365-2141.2009.07811.x
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发表时间：
2009-09
影响因子：
6.5
通讯作者：
Kay NE
中科院分区：
文献类型：
--
作者：
Shanafelt TD;Byrd JC;LaPLant B;Zent CS;Call T;Secreto C;Grever MR;Lin TS;Kay NE
Serum levels of pro-(vascular endothelial growth factor [VEGF]) and anti-(thrombospondin-1 [TSP]) angiogenic cytokines were prospectively measured in a phase II trial of chemoimmunotherapy (CIT) for chronic lymphocytic leukemia (CLL) patients(n=56). Pretreatment VEGF levels were lower among patients who achieved complete remission (CR) or nodular partial remission (nPR) relative to those with partial remission (PR) or stable/progressive disease (median 122.0 pg/ml vs. 246.8 pg/ml; p=0.03). VEGF:TSP ratio was lower (anti-angiogenic phenotype) among patients who achieved CR/nPR. The pretreatment VEGF:TSP ratio also correlated with overall survival (p=0.008). A pro-angiogenic profile appears associated with diminished response and inferior survival in CLL patients receiving CIT.
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影响因子：
158.5
作者：
Sandler, Alan;Gray, Robert;Johnson, David H.
通讯作者：
Johnson, David H.
影响因子：
20.3
作者：
Tam, Constantine S.;O'Brien, Susan;Keating, Michael J.
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Keating, Michael J.
影响因子：
158.5
作者：
Hurwitz, H;Fehrenbacher, L;Kabbinavar, F
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Kabbinavar, F
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2.7
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Kay, Neil E.;Shanafelt, Tait D.;Raza, Azra
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Raza, Azra
影响因子：
20.3
作者：
Byrd, JC;Peterson, BL;Larson, RA
通讯作者：
Larson, RA