A Cross-Sectional Study of the Impact of Spasticity on Daily Activities in Multiple Sclerosis
A Cross-Sectional Study of the Impact of Spasticity on Daily Activities in Multiple Sclerosis
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DOI：
10.1007/s40271-016-0173-0
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发表时间：
2016-12-01
影响因子：
3.6
通讯作者：
Marrie, Ruth Ann
中科院分区：
文献类型：
--
作者：
Bethoux, Francois;Marrie, Ruth Ann
在10，353名应答者中（应答率为66%），超过80%的人报告经历过痉挛，超过35%的人中度或重度受到僵硬、痉挛或疼痛的困扰，主要发生在下肢。更严重的痉挛状态与更差的残疾、移动性、膀胱功能和疲劳相关。据报道，痉挛最常干扰爬楼梯、行走和睡眠。大多数人报告接受痉挛治疗（主要是口服药物，拉伸，家庭锻炼和物理治疗），但不到一半的人报告对他们目前的治疗感到满意。绝大多数MS患者报告痉挛，并发现干扰许多日常活动。与此同时，患者往往对痉挛状态的治疗效果不满意。需要进行前瞻性研究，以更好地描述痉挛对MS患者的影响，并优化治疗策略。
Among the 10,353 responders (66 % response rate), over 80 % reported experiencing spasticity, and more than 35 % were moderately or greatly bothered by stiffness, spasms, or pain, predominantly in the lower extremities. More severe spasticity was associated with worse disability, mobility, bladder function, and fatigue. Spasticity was most frequently reported to interfere with stair climbing, walking, and sleep. Most individuals reported receiving treatment for spasticity (mainly oral medications, stretching, home exercise, and physical therapy), yet fewer than half reported being satisfied with their current treatment.Spasticity was reported by a large majority of patients with MS, and found to interfere with many daily activities. At the same time, patients were often dissatisfied with the effects of treatments for spasticity. Prospective studies are needed to better characterize the impact of spasticity in individuals with MS, and to optimize treatment strategies.