Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.
Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.
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化脓性汗腺炎：宿主微生物和免疫发病机制是未来重要方向的基础。
DOI：
10.1016/j.xjidi.2021.100001
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
MacLeod AS
中科院分区：
文献类型：
--
作者：
Jiang SW;Whitley MJ;Mariottoni P;Jaleel T;MacLeod AS
化脓性汗腺炎（HS）是一种慢性、复发-缓解性皮肤炎性疾病。该病的发病机制知之甚少，涉及多种因素，包括遗传、环境、宿主-微生物相互作用和免疫失调。特别是，随着疾病的进展，皮肤微生物组的组成发生变化，尽管尚不清楚这是原发性还是继发性过程。免疫调节治疗试验阐明了特异性免疫途径和细胞因子信号传导在疾病机制中的作用，如TNF-α、IL-1β、IL-12、IL-17、IL-23和补体。未来的研究应继续研究HS发病机制中微生物变化和免疫失调的原因和影响因素。
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1β, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis.