Endothelial progenitor cells during cerebrovascular disease
Endothelial progenitor cells during cerebrovascular disease
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DOI：
10.1161/01.str.0000149944.15406.16
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发表时间：
2005-01-01
期刊：
影响因子：
8.3
通讯作者：
Todd, K
中科院分区：
文献类型：
--
作者：
Ghani, U;Shuaib, A;Todd, K
背景和目的--内皮祖细胞与心脏或外周循环缺血后的内皮修复有关。目前还没有内皮祖细胞患有脑血管疾病的报道。我们介绍了我们在脑血管疾病患者中使用内皮祖细胞的经验。报告摘要-内皮祖细胞计数在卒中患者(急性卒中：中位数4.75%，范围0至33；稳定型卒中：中位数7.25%，范围0至43)和对照组(中位数15.5%，范围4.3%至50岁)之间存在显著差异(P<；0.001)，与年龄无关。EPC水平与Framingham冠状动脉危险评分(FCRs)显著相关(Rho=-0.349；P=0.002)。结论低EPC水平与心脏经历相似，可能在脑血管疾病的病理生理过程中起一定作用。
Background and Purpose - Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease.Summary of Report - EPC counts differed significantly ( P < 0.001) between stroke patients ( acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects ( median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score ( FCRS) (rho = - 0.349; P = 0.002).Conclusions - Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.