The neuropsychology of adult obsessive-compulsive disorder: A meta-analysis
The neuropsychology of adult obsessive-compulsive disorder: A meta-analysis
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DOI：
10.1016/j.cpr.2013.09.004
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发表时间：
2013-12-01
影响因子：
12.8
通讯作者：
Mittelman, Andrew
中科院分区：
文献类型：
--
作者：
Abramovitch, Amitai;Abramowitz, Jonathan S.;Mittelman, Andrew
近几十年来，关于强迫症（OCD）神经心理学的大量且多样的文献不断积累，结果却不一致。为了对这些文献进行定量总结，我们对115项研究（包括3452名患者）进行了荟萃分析，在10个神经心理学领域的测试中对成年强迫症患者和健康对照组进行了比较。在所有研究中，发现所有执行功能子领域、处理速度和持续注意力的平均效应量为中等。在视觉空间能力和工作记忆方面发现效应量较小。在非言语记忆方面发现效应量较大，而在言语记忆方面发现效应量较小，并且仅发现前者与执行功能受损有关。还对效应量的调节因素进行了研究。我们从临床意义以及对当前强迫症神经生物学模型的影响和方法学注意事项等方面对结果进行了讨论。（C）2013爱思唯尔有限公司。保留所有权利。
A vast and heterogeneous body of literature on the neuropsychology of obsessive-compulsive disorder (OCD) has accumulated in recent decades, yielding inconsistent results. In an attempt to quantitatively summarize the literature, we conducted a meta-analysis of 115 studies (including 3452 patients), comparing adult OCD patients with healthy controls on tests of 10 neuropsychological domains. Across studies, medium mean effect sizes were found for all executive function subdomains, processing speed, and sustained attention. Small effect sizes were found for visuospatial abilities and working memory. A large effect size was found for non-verbal memory whereas a small effect size was found for verbal memory, where only the former was found to be associated with impairments in executive functions. Moderators of effect sizes were also investigated. Results are discussed in terms of their clinical significance as well as their implications for current neurobiological models of OCD and methodological caveats. (C) 2013 Elsevier Ltd. All rights reserved.