Pubertal growth and epiphyseal fusion.
Pubertal growth and epiphyseal fusion.
复制标题
DOI：
10.6065/apem.2015.20.1.8
复制
发表时间：
2015-03
影响因子：
2.2
通讯作者：
Shim KS
中科院分区：
文献类型：
--
作者：
Shim KS
营养因子、细胞因子、旁分泌因子和内分泌因子的复杂网络与青春期生长和骨骺融合密切相关。重要的影响因素包括软骨细胞分化能力、生长板中活跃的多种分子通路、通过雌激素及其受体激活的生长激素-胰岛素样生长因子-I轴和骨骺融合。然而，这些现象的确切机制仍不清楚。更好地了解纵向骨生长中青春期生长突增和生长板闭合的详细过程将有助于我们开发有效促进青春期生长和延迟骨骺融合的方法，同时减少不良反应。
The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely related with pubertal growth and epiphyseal fusion. Important influencing factors include chondrocyte differentiation capacity, multiple molecular pathways active in the growth plate, and growth hormone-insulin-like growth factor-I axis activation and epiphyseal fusion through estrogen and its receptors. However, the exact mechanisms of these phenomena are still unclear. A better understanding of the detailed processes involved in the pubertal growth spurt and growth plate closure in longitudinal bone growth will help us develop methods to efficiently promote pubertal growth and delay epiphyseal fusion with fewer adverse effects.