Functional relevance of 'excitatory' GABA actions in cortical interneurons: A dynamical systems approach
Functional relevance of 'excitatory' GABA actions in cortical interneurons: A dynamical systems approach
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DOI：
10.1142/s0219635204000506
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发表时间：
2004-06-04
影响因子：
1.8
通讯作者：
Tsuda, Ichiro
中科院分区：
文献类型：
--
作者：
Fujii, Hiroshi;Aihara, Kazuyuki;Tsuda, Ichiro
GABA（A）受体介导的兴奋在成熟中枢神经系统中的非经典但经常报道的行为长期以来一直被认为是一个谜。我们的理论认为，皮质GABA能中间神经元的功能，这可能构成大脑的GABA中间神经元的子系统，是他们的能力，从抑制性行动的兴奋性行动取决于水平的时空活动的进展。从动力系统方法的角度来看，这种“兴奋性”GABA能反应可能有助于暂时调用吸引子样记忆，当被广泛激活时，例如，自上而下的信号作为类别信息或注意力，而GABA的持续背景状态将其作用改变为抑制，将记忆结构的动力学性质返回到吸引子废墟。
The non-classical, but frequently reported behavior of GABA(A) receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins.