Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat.
Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat.
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强效促性腺激素释放激素拮抗剂对雄性大鼠的抗生殖作用。
DOI：
10.1126/science.6774418
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Vale,W
中科院分区：
文献类型：
--
作者：
Rivier,C;Rivier,J;Vale,W
成年雄性大鼠注射促性腺激素释放激素拮抗剂[Ac-dedro-Pro1，Pcl-D-Phe2，D-Trp3，6]-Nα-MeLeu7-GnRH 2周后，睾酮分泌减少，性器官重量减少，精子发生受阻。这些结果证明了促性腺激素释放激素在维持生殖功能中的重要作用，并对男性生育能力的调节有一定的意义。
Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-Nα-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.