Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism
Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism
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DOI：
10.1016/s0022-510x(99)00068-4
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发表时间：
1999-04-01
影响因子：
4.4
通讯作者：
Lee, MY
中科院分区：
文献类型：
--
作者：
Lee, EJ;Hung, YC;Lee, MY
为了确定在大脑病理状态下贫血缺氧对脑血流动力学和脑代谢的影响，在术前诱发和未诱发慢性贫血的犬中进行中等程度的脑内出血（ICH）。通过动脉和上矢状窦（SSS）样本评估脑灌注压（CPP）和脑血流速度（CBFv）的变化，以及脑氧提取分数（CEO2）、动静脉氧含量差（AVDO（2））和乳酸（Lac）浓度的测定。在产生 ICH 之前，贫血动物 (n=8) 的脑 AVDO(2) 和动静脉 Lac 差异 (AVDLac) 显着降低，但 CBFv 和 CEO2 高于非贫血动物 (n=8)。贫血动物的CBFv在ICH后30分钟内开始下降，但非贫血动物的CBFv没有下降，并且发现两组之间的差异在2小时时显着（P
To determine the influence of anemic hypoxia on cerebral hemodynamics and brain metabolism during pathological conditions of the brain, moderate-sized intracerebral hemorrhage (ICH) was created in canines with and without preoperatively inducing chronic anemia. The changes in cerebral perfusion pressure (CPP) and cerebral blood flow velocities (CBFv) were evaluated as well as the determinations for cerebral extraction fraction of oxygen (CEO2), arteriovenous oxygen content difference (AVDO(2)) and lactate (Lac) concentrations through the arterial and superior sagittal sinus (SSS) samples. Before ICH production, anemic animals (n=8) showed a significant reduction in cerebral AVDO(2) and arteriovenous Lac difference (AVDLac) but had higher CBFv as well as CEO2 than did nonanemic animals (n=8). The CBFv began to decrease within 30 min after ICH in anemic but not in nonanemic animals, and the difference between the two groups was found to be significant at 2 h (P