Family, twin, and adoption studies of bipolar disorder
Family, twin, and adoption studies of bipolar disorder
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DOI：
10.1002/ajmg.c.20013
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发表时间：
2003-11-15
影响因子：
3.1
通讯作者：
Finn, CT
中科院分区：
文献类型：
--
作者：
Smoller, JW;Finn, CT
在过去的几十年里，家庭、双胞胎和收养研究在确定双相情感障碍的遗传流行病学方面是必不可少的。家族研究已经证明，受影响个体的一级亲属有患这种疾病的过度风险，而双胞胎研究（以及较小程度上的收养研究）表明，基因在很大程度上是这种家族聚集的原因。我们回顾这些研究，包括家庭风险和遗传性估计的大小，努力确定双相情感障碍的家庭亚型，以及家庭/遗传数据验证疾病分类界限的影响。总之，这些研究表明，双相情感障碍是表型和遗传复杂。(C)2003 Wiley-Liss，Inc.
Family, twin, and adoption studies have been essential in defining the genetic epidemiology of bipolar disorder over the past several decades. Family studies have documented that first-degree relatives of affected individuals have an excess risk of the disorder, while twin studies (and to a lesser extent, adoption studies) suggest that genes are largely responsible for this familial aggregation. We review these studies, including the magnitude of familial risk and heritability estimates, efforts to identify familial subtypes of bipolar disorder, and the implications of family/genetic data for validating nosologic boundaries. Taken together, these studies indicate that bipolar disorder is phenotypically and genetically complex. (C) 2003 Wiley-Liss, Inc.