Tumor self-responsive upconversion nanomedicines for theranostic applications
Tumor self-responsive upconversion nanomedicines for theranostic applications
复制标题
用于治疗诊断应用的肿瘤自响应上转换纳米药物
DOI：
10.1039/c9nr06450h
复制
发表时间：
2019
期刊：
影响因子：
6.7
通讯作者：
Yang Piaoping
中科院分区：
文献类型：
--
作者：
Xu Jiating;Gulzar Arif;Yang Dan;Gai Shili;He Fei;Yang Piaoping
迄今为止，恶性肿瘤仍然是最致命的疾病，每年在全世界造成820多万人死亡。近年来，基于稀土上转换发光纳米颗粒的纳米结构在多模态成像和治疗的集成中显示出显著的优势。与正常组织相比，肿瘤微环境（TME）具有独特的特征，包括高间质液压力，异常血管，缺氧和微酸性环境，以及高水平的谷胱甘肽（GSH）和过氧化氢（H2O2）。基于稀土上转换纳米粒子（UCNPs）的这些特性，设计对TME具有特异性反应的纳米药物，在降低副作用的前提下实现高效的肿瘤诊断和治疗，已成为抗肿瘤领域的研究热点。然而，系统总结TME响应上转换纳米药物（UCNMs）用于实现肿瘤自我增强治疗诊断学的综述迄今尚未发表。本文综述了近年来基于UCNP的纳米治疗药物的研究进展，重点介绍了TME响应性UCNMs的发展趋势。详细介绍了TME的一般特性，并系统地讨论了它们在TME响应UCNMs设计中的应用。基于近红外光激发光学成像技术，探讨了UCNMs在肿瘤诊断治疗中的优势，重点讨论了如何利用UCNMs实现TME介导的多模式成像引导治疗。
To date, malignant tumors continue to be the most lethal disease, causing more than 8.2 million deaths worldwide each year. In recent years, nanostructures based on rare-earth upconversion luminescent nanoparticles have shown significant advantages in the integration of multimodal imaging and therapy. Compared with normal tissues, the tumor microenvironment (TME) exhibits unique characteristics including high interstitial fluid pressure, abnormal blood vessels, a hypoxic and slightly acidic environment, and high levels of glutathione (GSH) and hydrogen peroxide (H2O2). According to these characteristics, increasing attention in the antitumor field has been given to designing nanomedicines with specific responses to the TME based on rare-earth upconversion nanoparticles (UCNPs) and to achieving efficient tumor diagnosis and treatment under the premise of reducing side effects. Nevertheless, a review that systematically summarizes TME-responsive upconversion nanomedicines (UCNMs) for realizing tumor self-enhanced theranostics has not been published to date. In this review, we summarize the recent progress made in UCNP-based nanotherapeutics by highlighting the increasingly developing trend of TME-responsive UCNMs. The general characteristics of the TME are introduced in detail and their utilization in designing TME-responsive UCNMs is systematically discussed. Based on NIR light-excited optical imaging, we discuss the superiority of UCNMs when applied in tumor theranostics with an emphasis on how to use them to realize TME-mediated multimodal imaging-guided therapy.