Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53-and p16/Rb-dependent cell cycle regulator proteins
Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53-and p16/Rb-dependent cell cycle regulator proteins
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DOI：
10.1111/j.1440-1827.2008.02307.x
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发表时间：
2008-12-01
影响因子：
2.2
通讯作者：
Tsuneyoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Iwasa, Atsuko;Oda, Yoshinao;Tsuneyoshi, Masazumi
卵巢成熟囊性畸胎瘤（MCT）很少发生恶性转化为鳞状细胞癌（SCC）。虽然p53肿瘤抑制基因和蛋白质的改变已被证明，很少有研究分析其他分子的变化，导致这种恶性转化。本研究的目的是调查21例发生在MCT的SCC样本中已知的p53和p16/Rb依赖性细胞周期调控蛋白的表达改变，以及它们的表达与细胞增殖和组织学特征之间的关联。p53蛋白的过度表达在14例（67%）SCC中观察到，而4例（19%）有p53基因的点突变。18例（86%）SCC中p16蛋白表达降低，而11例（52%）SCC中p16基因异常（29%）和点突变（33%）。p53和Rb的过度表达之间存在显著相关性（P = 0.0010），p53和Rb的过度表达分别与细胞增殖的增加显著相关。结果表明p53和p16-Rb通路的改变与MCT中出现的SCC相关。
Ovarian mature cystic teratomas (MCT) uncommonly undergo malignant transformation to squamous cell carcinoma (SCC). While alterations in the p53 tumor suppressor gene and protein have been shown, few studies have analyzed other molecular changes leading to this malignant conversion. The purpose of the present study was to investigate 21 samples of SCC arising in MCT for altered expression in known p53- and p16/Rb-dependent cell cycle regulatory proteins, and the association between their expression and cellular proliferation and histological features. Overexpression of the p53 protein was observed in 14 SCC (67%), while four (19%) had point mutations in the p53 gene. Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). Furthermore, a statistically significant correlation was observed between p53 and Rb overexpression (P = 0.0010), and the overexpression of both p53 and Rb was respectively significantly correlated with increased cellular proliferation. The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT.