Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia
Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia
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DOI：
10.1038/sj.bjc.6690209
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发表时间：
1999-03-01
影响因子：
8.8
通讯作者：
Arlett, CF
中科院分区：
文献类型：
--
作者：
Inskip, HM;Kinlen, LJ;Arlett, CF
对95名英国共济失调-毛细血管扩张症患者的178名父母和236名祖父母的癌症死亡率进行了调查。对于父母和祖父母来说，各种原因或癌症的死亡率都没有明显高于全国人口的死亡率。在母亲中，3例死于乳腺癌的标准化死亡率为3.37(95%可信区间：0.69-9.84)。相比之下，祖母中没有过多的乳腺癌，基于三例死亡，标准化死亡率为0.89(95%可信区间：0.18-2.59)。这是英国对共济失调-毛细血管扩张症患者家庭进行的最大规模的研究，但尽管如此，这项研究规模很小，范围也很广。然而，结合其他国家的数据，女性杂合子患乳腺癌风险的增加仍然很明显，尽管比之前认为的要低。
Mortality from cancer among 178 parents and 236 grandparents of 95 British patients with ataxia-telangiectasia was examined. For neither parents nor grandparents was mortality from all causes or from cancer appreciably elevated over that of the national population. Among mothers, three deaths from breast cancer gave rise to a standardized mortality ratio of 3.37 (95% confidence interval (CI): 0.69-9.84). In contrast, there was no excess of breast cancer in grandmothers, the standardized mortality ratio being 0.89 (95% CI: 0.18-2.59), based on three deaths. This is the largest study of families of ataxia-telangiectasia patients conducted in Britain but, nonetheless, the study is small and Cis are wide. However, taken together with data from other countries, an increased risk of breast cancer among female heterozygotes is still apparent, though lower than previously thought.