The soil and the seed: The relationship between Descemet's membrane and the corneal endothelium.
The soil and the seed: The relationship between Descemet's membrane and the corneal endothelium.
复制标题
DOI：
10.1016/j.exer.2022.109376
复制
发表时间：
2023-02
影响因子：
3.4
通讯作者：
Patel, Sangita P.
中科院分区：
文献类型：
--
作者：
Petrela, Redion B.;Patel, Sangita P.
Descemet’s membrane (DM), the basement membrane of the corneal endothelium, is formed from the extracellular matrix (ECM) secreted by corneal endothelial cells. The ECM supports the growth and function of the corneal endothelial cells. Changes to DM are central to the diagnosis of the most common corneal endothelial disease, Fuchs endothelial corneal dystrophy (FECD). Changes in DM are also noted in systemic diseases such as diabetes mellitus. In FECD, the DM progressively accumulates guttae, “drop-like deposits” that disrupt the corneal endothelial cell monolayer. While the pathophysiologic changes to corneal endothelial cells in the course of FECD have been well described and reviewed, the changes to DM have received limited attention. The reciprocity of influence between the corneal endothelial cells and DM demands full attention to the latter in our search for novel treatment and preventive strategies. In this review, we discuss what is known about the formation and composition of DM and how it changes in FECD and other conditions. We review characteristics of guttae and the interplay between corneal endothelial cells and guttae, particularly as it might apply to future cell-based and genetic therapies for FECD.
登录
查看更多内容
影响因子：
0.7
作者：
Eghrari AO;Gottsch JD
通讯作者：
Gottsch JD
影响因子：
7.8
作者：
Gendron SP;Rochette PJ
通讯作者：
Rochette PJ
影响因子：
2.8
作者：
Gattey, Devin;Zhu, Angela Y.;Jun, Albert S.
通讯作者：
Jun, Albert S.
DOI：
10.1007/s00417-018-3914-z
发表时间：
2018-03-01
影响因子：
2.7
作者：
Bakhoum, Mathieu F.;Wu, Wei-Pu;Tsang, Stephen H.
通讯作者：
Tsang, Stephen H.
影响因子：
4.4
作者：
De Roo, An-Katrien;Wouters, Jasper;van den Oord, Joost J.
通讯作者：
van den Oord, Joost J.