Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort
Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort
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DOI：
10.3945/ajcn.112.050997
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发表时间：
2013-03-01
影响因子：
7.1
通讯作者：
Clavel-Chapelon, Francoise
中科院分区：
文献类型：
--
作者：
Fagherazzi, Guy;Vilier, Alice;Clavel-Chapelon, Francoise
背景资料：它已被广泛显示，主要是在美国人群中，含糖饮料（SSB）与2型糖尿病（T2 D）的风险增加有关，但对人工甜味饮料（ASB）的影响知之甚少。目的：我们评估了自我报告的SSB，ASB，和100%的果汁消费和T2 D风险超过14年的随访，在法国前瞻性流行病学研究中，欧洲癌症和营养队列前瞻性研究：设计：从1993年开始，共随访了66,118名女性，随访期间诊断出1369例T2 D事件。考克斯回归模型被用来估计HR和95%CI为T2 D risk.Results：在消费者的平均消费量为328和568毫升/周的SSB和ASB，分别。与非消费者相比，SSB和ASB消费者中最高四分位数的女性患T2 D的风险增加，对于消费>359和>603 mL/wk的SSB和ASB的女性，HR（95% CI）分别为1.34（1.05，1.71）和2.21（1.56，3.14）。在两种类型饮料的消费量的四分位数中，也观察到T2 D风险的强阳性趋势（分别为P = 0.0088和P < 0.0001）。在敏感性分析中，关联部分由BMI介导，尽管仍有很强的显著独立效应。100%的果汁消费量没有观察到相关性。结论：SSB消费量和ASB消费量均与T2 D风险增加相关。我们不能排除我们没有控制的ASB消费以外的因素与糖尿病相关，需要随机试验来证明ASB消费和T2 D之间的因果关系。美国临床营养杂志2013;97：517-23。
Background: It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs).Objective: We evaluated the association between self-reported SSB, ASB, and 100% fruit juice consumption and T2D risk over 14 y of follow-up in the French prospective Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort.Design: A total of 66,118 women were followed from 1993, and 1369 incident cases of T2D were diagnosed during the follow-up. Cox regression models were used to estimate HRs and 95% CIs for T2D risk.Results: The average consumption of sweetened beverages in consumers was 328 and 568 mL/wk for SSBs and ASBs, respectively. Compared with nonconsumers, women in the highest quartiles of SSB and ASB consumers were at increased risk of T2D with HRs (95% CIs) of 1.34 (1.05, 1.71) and 2.21 (1.56, 3.14) for women who consumed >359 and >603 mL/wk of SSBs and ASBs, respectively. Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage (P = 0.0088 and P < 0.0001, respectively). In sensitivity analyses, associations were partly mediated by BMI, although there was still a strong significant independent effect. No association was observed for 100% fruit juice consumption.Conclusions: Both SSB consumption and ASB consumption were associated with increased T2D risk. We cannot rule out that factors other than ASB consumption that we did not control for are responsible for the association with diabetes, and randomized trials are required to prove a causal link between ASB consumption and T2D. Am J Clin Nutr 2013;97:517-23.