Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging
Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging
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DOI：
10.1016/j.neurobiolaging.2019.10.003
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Spencer, Richard G.
中科院分区：
文献类型：
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作者：
Bouhrara, Mustapha;Rejimon, Abinand C.;Spencer, Richard G.
局部脑髓鞘形成和衰老之间的关系一直是深入研究的主题，磁共振成像可能是阐明这一点的最有效方式。然而，大多数这些研究使用非特异性的方法来探测髓鞘含量，包括扩散张量成像，磁化传递率和弛豫时间。在本研究中，我们使用了BMC-mcDESPOT分析，一种直接和特异性的方法，用于髓鞘水分数（MWF），髓鞘含量的替代成像。我们研究了年龄相关的差异MWF在几个大脑区域的认知未受损的参与者的大队列，跨越了很大的年龄范围。我们的研究结果表明，二次，倒U形，MWF和年龄之间的关系，在所有的大脑区域的调查，这表明髓鞘持续到中年，然后在老年人减少。我们还观察到，正如预期的那样，这些与年龄相关的差异在不同的大脑区域中有所不同。我们的研究结果提供了证据，年龄和髓鞘之间的非线性关联在一个大样本的良好特征的成年人，使用直接髓鞘含量成像方法。(C)2019爱思唯尔公司All rights reserved.
The relationship between regional brain myelination and aging has been the subject of intense study, with magnetic resonance imaging perhaps the most effective modality for elucidating this. However, most of these studies have used nonspecific methods to probe myelin content, including diffusion tensor imaging, magnetization transfer ratio, and relaxation times. In the present study, we used the BMC-mcDESPOT analysis, a direct and specific method for imaging of myelin water fraction (MWF), a surrogate of myelin content. We investigated age-related differences in MWF in several brain regions in a large cohort of cognitively unimpaired participants, spanning a wide age range. Our results indicate a quadratic, inverted U-shape, relationship between MWF and age in all brain regions investigated, suggesting that myelination continues until middle age followed by decreases at older ages. We also observed that these age-related differences vary across different brain regions, as expected. Our results provide evidence for nonlinear associations between age and myelin in a large sample of well-characterized adults, using a direct myelin content imaging method. (C) 2019 Elsevier Inc. All rights reserved.