[Targeted and controlled release of drugs using magnetoliposomes].
[Targeted and controlled release of drugs using magnetoliposomes].
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磁脂质体药物靶向控释[J].
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
M. Babincová
中科院分区：
文献类型：
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作者：
M. Babincová
The present paper deals with a stable drug delivery system which allows to concentrate the drug in a desired site and its programmable release. For these purposes the present authors have suggested to use magnetoliposomes (liposomes with enwrapped magnetite particles in their bilayers) which are magnetosensitive and may be maneuvered to the given site in the organism. Due to the magnetite particles, which are strong microwave absorbers, magnetoliposomes can be heated to higher temperatures which may subsequently lead to a leakage of encapsulated drug. Influence of static magnetic field on liposomes in the blood-stream was analyzed theoretically. Fluorescence spectrophotometry was used to determine the relationship between doses of microwave radiation and the extent of drug release.
