Exploring polymeric micelles for improved delivery of anticancer agents: recent developments in preclinical studies.
Exploring polymeric micelles for improved delivery of anticancer agents: recent developments in preclinical studies.
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DOI：
10.3390/pharmaceutics5010201
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发表时间：
2013-03-22
期刊：
影响因子：
5.4
通讯作者：
Fan W
中科院分区：
文献类型：
--
作者：
Tan C;Wang Y;Fan W
聚合物胶束作为一种多功能的药物释放系统，在溶解疏水性抗癌药物方面表现出独特的优势，同时消除了有毒有机溶剂和表面活性剂的使用。然而，聚合物胶束作为药物载体用于癌症治疗的真正前景在于它们优先提高肿瘤中药物暴露并实现增强的抗癌功效的潜在能力，这仍然有待充分利用。在这里，我们回顾了在肿瘤中表现出增强渗透和保留作用的各种胶束构建体、增强胶束药物抗癌功效的靶向配体以及适合递送质粒DNA和小干扰RNA的多聚物胶束系统。总之，这些在动物模型中的临床前研究有助于我们进一步探索聚合物胶束作为靶向癌症治疗的新兴药物载体。
As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles as drug carriers for cancer therapy resides in their potential ability to preferentially elevate drug exposure in the tumor and achieve enhanced anticancer efficacy, which still remains to be fully exploited. Here, we review various micellar constructs that exhibit the enhanced permeation and retention effect in the tumor, the targeting ligands that potentiate the anticancer efficacy of micellar drugs, and the polyplex micelle systems suitable for the delivery of plasmid DNA and small interference RNA. Together, these preclinical studies in animal models help us further explore polymeric micelles as emerging drug carriers for targeted cancer therapy.