Activity-dependent functions of non-electrical glial cells
Activity-dependent functions of non-electrical glial cells
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DOI：
10.1093/jb/mvy023
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
D. Kato;Kei Eto;J. Nabekura;H. Wake
中科院分区：
文献类型：
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作者：
D. Kato;Kei Eto;J. Nabekura;H. Wake
电活动对大脑功能至关重要。然而，在中枢神经系统中，神经元，即电活性细胞，比非电胶质细胞数量少。非电成分通过包裹突触、使轴突髓鞘化和吞噬神经元成分，取决于电神经元活动来修改神经回路的功能。此外，最近的证据表明，它们通过调节神经回路，最终影响其行为，从而导致神经和精神疾病。在这篇综述中，我们强调了神经胶质细胞的生理功能，特别是电活动依赖的过程，以进一步了解它们在脑功能中的作用。
Electrical activity is essential for brain function. However, neurons, the electrically active cells, are less numerous than the non-electrical glial cells in the central nervous system. The non-electrical components modify the function of neural circuits, depending on the electrical neuronal activity, by wrapping synapses, myelinating axons and phagocytozing the neuronal components. Moreover, recent evidence has suggested that they contribute to neurological and psychiatric disease by regulating neuronal circuits, ultimately affecting their behaviour. In this review, we highlight the physiological functions of glial cells, particularly the electrical activity-dependent processes, to provide further insight into their role in brain function.