WALLERIAN DEGENERATION AFTER CEREBRAL INFARCTION - EVALUATION WITH SEQUENTIAL MR IMAGING
WALLERIAN DEGENERATION AFTER CEREBRAL INFARCTION - EVALUATION WITH SEQUENTIAL MR IMAGING
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DOI：
10.1148/radiology.172.1.2740501
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发表时间：
1989-07-01
期刊：
影响因子：
19.7
通讯作者：
TAVERAS, JM
中科院分区：
文献类型：
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作者：
KUHN, MJ;MIKULIS, DJ;TAVERAS, JM
动态信号强度变化的磁共振成像在活动性和慢性沃勒变性的皮质脊髓束进行了评价。本文对43例脑梗塞后沃勒变性的MRI表现进行了研究。在可能的情况下，急性卒中患者在症状发作时前瞻性地进行MR成像检查，然后在几个月内每周进行一次。在临床症状出现后的第1个月，显示局灶性梗死，无远端轴突变性。4周时，在皮质脊髓束的T2加权像上出现一条边界清晰的低信号带。10-14周后，信号变得永久高强度。几年后，伴随同侧脑干萎缩发生。在4 - 14周之间的T2加权成像上观察到的暗信号强度被认为主要是由于暂时性的脂质-蛋白质比率增加。
The dynamic signal intensity changes at magnetic resonance (MR) imaging in active and chronic wallerian degeneration in the corticospinal tract were evaluated. Forty-three patients with wallerian degeneration seen on MR images after cerebral infarction were studied. When possible, patients with acute stroke were examined with MR imaging prospectively at the onset of symptoms and then at weekly intervals for several months. Focal infarction without distal axonal degeneration is demonstrated for the 1st month following onset of clinical symptoms. At 4 weeks, a well-defined band of hypointense signal appears on T2-weighted images in the topographic distribution of the corticospinal tract. After 10-14 weeks, the signal becomes permanently hyperintense. Over several years, accompanying ipsilateral brain stem shrinkage occurs. The dark signal intensity observed on T2-weighted imaged between 4 and 14 weeks is believed to result primarily from transitory increased lipid-protein ration.