Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice
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DOI：
10.1016/j.neulet.2008.06.033
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发表时间：
2008-08-22
影响因子：
2.5
通讯作者：
Hara, Hideaki
中科院分区：
文献类型：
--
作者：
Nonaka, Yuko;Shimazawa, Masamitsu;Hara, Hideaki
我们评估了正压高氧（NBO）和依达拉奉（一种有效的羟自由基清除剂）联合治疗对脑卒中后急性脑损伤的潜在神经保护作用。脑中动脉丝状闭塞2小时小鼠分别在缺血时单独给予NBO （95% O-2）、缺血后单独给予依达拉奉（1.5 mg/kg，缺血后静脉注射）、同时给予这两种治疗（联合）或给药。再灌注后22小时进行组织学和神经学评分。联合组梗死面积明显减少[36.3 +/- 63 mm(3) (n = 10)]，对照组：65.5 +/- 5.9 mm(3) （n = 14）
We evaluated the potential neuroprotective effects of combination treatment with normobaric hyperoxia (NBO) and edaravone, a potent scavenger of hydroxyl radicals, on acute brain injuries after stroke. Mice subjected to 2-h filamental middle cerebral artery occlusion were treated with NBO (95% O-2, during the ischemia) alone, with edaravone (1.5 mg/kg, intravenously after the ischemia) alone, with both of these treatments (combination), or with vehicle. The histological and neurological score were assessed at 22-h after reperfusion. Infarct volume was significantly reduced in the combination group [36.3 +/- 63 mm(3) (n = 10) vs. vehicle: 65.5 +/- 5.9 mm(3) (n = 14) P