Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati
Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati
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DOI：
10.1371/journal.pntd.0005863
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发表时间：
2017-09-01
影响因子：
3.8
通讯作者：
Solomon, Anthony W.
中科院分区：
文献类型：
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作者：
Cama, Anaseini;Muller, Andreas;Solomon, Anthony W.
目的在所罗门群岛、斐济等一些太平洋岛国，活动性沙眼常见，但眼部沙眼衣原体（Ct）感染和沙眼倒睫（TT）罕见。在基里巴斯人口最多的岛屿塔拉瓦岛，活动性沙眼征象“沙眼性滤泡性炎症”(TF) 和 TT 的患病率都很高，需要进行干预。我们试图估计基里巴斯基里蒂马蒂岛 TF、TT、眼部 Ct 感染和抗 Ct 抗体的患病率，以评估这些参数之间的局部关系，并帮助确定塔拉瓦以外的基里巴斯群岛是否需要采取沙眼干预措施。方法作为全球沙眼绘图项目 (GTMP) 的一部分，我们在基里蒂马蒂岛检查了 406 名 1-9 岁儿童的活动性沙眼。我们收集了患有活动性沙眼的 1-9 岁儿童的结膜拭子（用于针对 Ct 质粒靶标的液滴数字 PCR），并系统地选择了没有活动性沙眼的 1-9 岁儿童。我们收集了所有 1-9 岁儿童的干血斑（用于抗 Pgp3 ELISA）。我们还检查了 416 名 15 岁以上成年人的 TT。根据五年年龄范围内的年龄 (TF) 或年龄和性别 (TT) 调整 TF 和 TT 的患病率。结果 1-9 岁儿童中 TF 的年龄调整患病率为 28%（95% 置信区间 [CI]：24-35）。 15 岁以上人群中经年龄和性别调整后的 TT 患病率为 0.2%（95% CI：0.1-0.3%）。 193 份无活动性沙眼儿童拭子中的 26 份（13.5%）和 118 份活动性沙眼儿童拭子中的 58 份（49.2%）Ct DNA 呈阳性。 397 名儿童中的 210 名 (53%) 具有抗 Pgp3 抗体。两种感染（p
ObjectiveIn some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous-inflammation-follicular" (TF) and TT are present at prevalences warranting intervention. We sought to estimate prevalences of TF, TT, ocular Ct infection, and anti-Ct antibodies on Kiritimati Island, Kiribati, to assess local relationships between these parameters, and to help determine the need for interventions against trachoma on Kiribati islands other than Tarawa.MethodsAs part of the Global Trachoma Mapping Project (GTMP), on Kiritimati, we examined 406 children aged 1-9 years for active trachoma. We collected conjunctival swabs (for droplet digital PCR against Ct plasmid targets) from 1-9-year-olds with active trachoma, and a systematic selection of 1-9-year-olds without active trachoma. We collected dried blood spots (for anti-Pgp3 ELISA) from all 1-9-year-old children. We also examined 416 adults aged >= 15 years for TT. Prevalence of TF and TT was adjusted for age (TF) or age and gender (TT) in five-year age bands.ResultsThe age-adjusted prevalence of TF in 1-9-year-olds was 28% (95% confidence interval [CI]: 24-35). The age-and gender-adjusted prevalence of TT in those aged >= 15 years was 0.2% (95% CI: 0.1-0.3%). Twenty-six (13.5%) of 193 swabs from children without active trachoma, and 58 (49.2%) of 118 swabs from children with active trachoma were positive for Ct DNA. Two hundred and ten (53%) of 397 children had anti-Pgp3 antibodies. Both infection (p