Introduction of Low-Barrier High-Throughput Experimentation in the Undergraduate Laboratory: Suzuki—Miyaura Reaction
Introduction of Low-Barrier High-Throughput Experimentation in the Undergraduate Laboratory: Suzuki—Miyaura Reaction
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本科实验室低屏障高通量实验介绍：铃木—宫浦反应
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
S. Berritt
中科院分区：
文献类型：
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作者：
Jisun Lee;Jason R. Schmink;S. Berritt
当代大学生实验室实验结合平行的微型实验开发了定义明确的钯催化Suzuki-Miyaura交叉偶联4-氟苯基硼酸与4-氯-和4-溴苯甲醚使用11种不同的膦配体和一个无配体的控制。该实验室向学生介绍了在学术和工业研究环境中广泛使用的低屏障高通量实验（HTE）技术。本实验补充了有机化学，无机化学和有机金属化学讲座课程中讨论的当前主题，并有助于加强学生对过渡金属介导的交叉偶联反应基本概念的理解。学生还接触到研究环境中使用的常用分析工具（薄层色谱法（TLC）和高压液相色谱法（HPLC）），以分析相应的实验数据。
A contemporary undergraduate laboratory experiment incorporating parallel microscale experimentation was developed for the well-defined palladium catalyzed Suzuki–Miyaura cross coupling of 4-fluorophenylboronic acid with both 4-chloro- and 4-bromoanisole using 11 diverse phosphine ligands and one ligandless control. This laboratory introduces students to low-barrier high-throughput experimentation (HTE) technique that is widely utilized in both academic and industrial research settings. This experiment compliments current topics discussed in organic chemistry, inorganic chemistry, and organometallic chemistry lecture courses and serves to reinforce the students’ understanding of fundamental concepts of transition metal mediated cross-coupling reactions. Students are also exposed to common analytical tools (thin layer chromatography (TLC) and high-pressure liquid chromatography (HPLC)) used in research settings to analyze the corresponding experimental data.