Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy.
Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy.
复制标题
妊娠期 SARS-CoV-2 感染和疫苗接种导致母婴脐带抗体功能不同。
DOI：
10.1101/2023.05.01.538955
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lu,LenetteL
中科院分区：
文献类型：
--
作者：
Adhikari,EmilyH;Lu,Pei;Kang,YeJin;McDonald,AnnR;Pruszynski,JessicaE;Bates,TimothyA;McBride,SavannahK;Trank-Greene,Mila;Tafesse,FikaduG;Lu,LenetteL
妊娠期免疫接种是一种重要的工具，可以用来保护免疫系统不成熟的婴儿，但疫苗诱导的抗体如何转移到胎盘并保护母胎二分体仍不清楚。在这里，我们比较了来自妊娠期接受mRNA COVID-19疫苗、感染SARS-CoV-2或同时接受这两种免疫暴露的个体的匹配母婴脐带血。我们发现，与感染相比，疫苗接种富集了一些但不是所有的抗体中和活性和Fc效应子功能。观察到Fc功能优先转运至胎儿，而非中和。与感染相比，免疫增强了IgG 1介导的抗体功能，抗体翻译后唾液酸化和岩藻糖基化发生变化，对胎儿抗体功能效价的影响大于母体抗体功能效价。因此，与母体反应相比，疫苗增强胎儿中抗体功能的大小、效力和广度更多地由抗体糖基化和Fc效应子功能驱动，这突出了在SARS-CoV-2成为地方病时保护新生儿的产前机会。
Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature immune system but how vaccine-induced antibodies transfer to the placenta and protect the maternal-fetal dyad remains unclear. Here, we compare matched maternal-infant cord blood from individuals who in pregnancy received mRNA COVID-19 vaccine, were infected by SARS-CoV-2, or had the combination of these two immune exposures. We find that some but not all antibody neutralizing activities and Fc effector functions are enriched with vaccination compared to infection. Preferential transport to the fetus of Fc functions and not neutralization is observed. Immunization compared to infection enriches IgG1-mediated antibody functions with changes in antibody post-translational sialylation and fucosylation that impact fetal more than maternal antibody functional potency. Thus, vaccine enhanced antibody functional magnitude, potency and breadth in the fetus are driven more by antibody glycosylation and Fc effector functions compared to maternal responses, highlighting prenatal opportunities to safeguard newborns as SARS-CoV-2 becomes endemic.