Absolute arterial cerebral blood volume quantification using inflow vascular-space-occupancy with dynamic subtraction magnetic resonance imaging
Absolute arterial cerebral blood volume quantification using inflow vascular-space-occupancy with dynamic subtraction magnetic resonance imaging
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DOI：
10.1038/jcbfm.2010.16
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发表时间：
2010-07-01
影响因子：
6.3
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
Donahue, Manus J.;Sideso, Ediri;Jezzard, Peter
在颈内动脉狭窄闭塞症(ICA)患者中，脑血流量可通过动脉脑血容量(ACBV)的自我调节增加来维持。因此，确定CBV的特征可能有助于理解血流动力学代偿策略。提出了一种新的“流入血管占位动态减影(iVASO-DS)”MRI方法，该方法在没有对比剂的情况下，利用有无血流信号的图像之间的差异来量化a CBV(毫升血液/100毫升实质)。对8例健康志愿者(n=8，年龄29±5岁)、7例轻度颈内动脉狭窄(n=7，年龄72±8岁)和10例重度(n=10，年龄73±8岁)颈内动脉狭窄患者进行了IVASO-DS对比研究。测量对照组左右半球的aCBV，并与行业标准动态敏感性对比(DSC)、对侧(CONT)和同侧(IPS)的最大狭窄程度进行比较。在考虑了传输时间差异后，IVASO对比度与DSC-CBV显著相关(R=0.67，P<；0.01)。对照组灰质aCBV为1.60+/-0.10，对照组为1.61+/-0.20；轻度狭窄组为1.59+/-0.38，iPS为1.65+/-0.37；重度狭窄组为1.72+/-0.18，1.58+/-0.20。41%的患者ACBV是不对称的(P<；0.01)，而在任何对照组中都没有发现不对称。在现有血流动力学文献的背景下，讨论了iVASO-DS用于自动调节研究的潜力。《脑血流与代谢杂志》(2010年)30期，1329-1342年；doi：10.1038/jcbfm.2010.16；2010年2月10日在线出版
In patients with steno-occlusive disease of the internal carotid artery (ICA), cerebral blood flow may be maintained by autoregulatory increases in arterial cerebral blood volume (aCBV). Therefore, characterizing aCBV may be useful for understanding hemodynamic compensation strategies. A new 'inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS)' MRI approach is presented where aCBV (mL blood/100mL parenchyma) is quantified without contrast agents using the difference between images with and without inflowing blood water signal. The iVASO-DS contrast mechanism is investigated (3.0 T, spatial resolution = 2.4x2.4x5mm(3)) in healthy volunteers (n = 8; age = 29+/-5 years), and patients with mild (n = 7; age = 72+/-8 years) and severe (n = 10; age = 73+/-8 years) ICA stenoses. aCBV was quantified in right and left hemispheres in controls, and, alongside industry standard dynamic susceptibility contrast (DSC), contralateral (cont), and ipsilateral (ips) to maximum stenosis in patients. iVASO contrast significantly correlated (R = 0.67, P < 0.01) with DSC-CBV after accounting for transit time discrepancies. Gray matter aCBV (mL/100 mL) was 1.60+/-0.10 (right) versus 1.61+/-0.20 (left) in controls, 1.59+/-0.38 (cont) and 1.65+/-0.37 (ips) in mild stenosis patients, and 1.72+/-0.18 (cont) and 1.58+/-0.20 (ips) in severe stenosis patients. aCBV was asymmetric (P < 0.01) in 41% of patients whereas no asymmetry was found in any control. The potential of iVASO-DS for autoregulation studies is discussed in the context of existing hemodynamic literature. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1329-1342; doi:10.1038/jcbfm.2010.16; published online 10 February 2010