High-Frequency Pallidal Stimulation Disrupts Information Flow through the Pallidum by GABAergic Inhibition
High-Frequency Pallidal Stimulation Disrupts Information Flow through the Pallidum by GABAergic Inhibition
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DOI：
10.1523/jneurosci.4144-11.2013
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发表时间：
2013-02-06
影响因子：
5.3
通讯作者：
Nambu, Atsushi
中科院分区：
文献类型：
--
作者：
Chiken, Satomi;Nambu, Atsushi
为阐明深部脑刺激（DBS）靶向苍白球内段（GPi）的作用机制，观察了正常清醒猴局部微电刺激时GPi和苍白球外段（GPe）的神经元活动。单脉冲刺激GPi引起邻近GPi神经元的短暂抑制，这是由GABA（A）受体介导的。对GPi的高频刺激通过激活GABA（A）和GABA（B）受体而完全抑制GPi神经元的自发放电。局部单脉冲刺激直接兴奋部分GPi神经元。这种直接诱发的反应也被通过GABA（A）受体的高频刺激所抑制。与GPi相反，单脉冲和高频刺激GPe引起由邻近GPe神经元的GABA能抑制和谷氨酸能兴奋组成的复杂反应。在高频GPi刺激期间，GPi神经元的皮层诱发的三相反应被完全抑制。这些发现表明，GPi-DBS通过强烈的GABA能抑制分离GPi中的输入和输出，并破坏通过GPi的信息流。
To elucidate the mechanism of deep brain stimulation (DBS) targeting the internal segment of the globus pallidus (GPi), neuronal activity of the GPi and the external segment of the globus pallidus (GPe) was examined during local electrical microstimulation in normal awake monkeys. Single-pulse stimulation of the GPi evoked brief inhibition in neighboring GPi neurons, which was mediated by GABA(A) receptors. High-frequency stimulation of the GPi completely inhibited spontaneous firings of GPi neurons by activation of GABA(A) and GABA(B) receptors. Local single-pulse stimulation directly excited some GPi neurons. Such directly evoked responses were also inhibited by high-frequency stimulation through GABA(A) receptors. In contrast to the GPi, single-pulse and high-frequency stimulation of the GPe induced complex responses composed of GABAergic inhibition and glutamatergic excitation in neighboring GPe neurons. Cortically evoked triphasic responses of GPi neurons were completely inhibited during high-frequency GPi stimulation. These findings suggest that GPi-DBS dissociates inputs and outputs in the GPi by intense GABAergic inhibition and disrupts information flow through the GPi.