The role of dynamic instability in microtubule organization.
The role of dynamic instability in microtubule organization.
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DOI：
10.3389/fpls.2014.00511
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发表时间：
2014
影响因子：
5.6
通讯作者：
Murata T
中科院分区：
文献类型：
--
作者：
Horio T;Murata T
微管是真核细胞的三大骨架之一。由GTP结合的α-和β-微管蛋白分子组成的异源二聚体聚集形成微管原丝，微管原丝横向结合形成中空微管。微管蛋白具有GTP酶活性，并且与β-微管蛋白分子结合的GTP分子在掺入聚合微管后不久被水解。GTP水解改变微管蛋白分子的构象并驱动微管的动力学行为。微管快速聚合的时期与收缩的时期交替出现，这一过程被称为动态不稳定性。在植物中，动态不稳定性在决定微管组织成阵列中起着关键作用，并且这些阵列在整个细胞周期中变化。在这篇综述中，我们描述了调控微管动力学和动力学不稳定性的机制，并讨论了动力学不稳定性如何塑造植物细胞中的微管组织。
Microtubules are one of the three major cytoskeletal components in eukaryotic cells. Heterodimers composed of GTP-bound α- and β-tubulin molecules polymerize to form microtubule protofilaments, which associate laterally to form a hollow microtubule. Tubulin has GTPase activity and the GTP molecules associated with β-tubulin molecules are hydrolyzed shortly after being incorporated into the polymerizing microtubules. GTP hydrolysis alters the conformation of the tubulin molecules and drives the dynamic behavior of microtubules. Periods of rapid microtubule polymerization alternate with periods of shrinkage in a process known as dynamic instability. In plants, dynamic instability plays a key role in determining the organization of microtubules into arrays, and these arrays vary throughout the cell cycle. In this review, we describe the mechanisms that regulate microtubule dynamics and underlie dynamic instability, and discuss how dynamic instability may shape microtubule organization in plant cells.
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影响因子：
11.6
作者：
Dixit, R;Cyr, R
通讯作者：
Cyr, R
影响因子：
4
作者：
Austin, JR;Seguí-Simarro, JM;Staehelin, LA
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